DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d21

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_083130.1	Gene:	Tbc1d21 / 74286	MGIID:	1921536	Length:	336	Species:	Mus musculus

Alignment Length:	344	Identity:	79/344 - (22%)
Similarity:	146/344 - (42%)	Gaps:	34/344 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 NNLPDRQRV-----ERGHPLTETQWLEFQTPDGRISDSAR-IKELIFRGGVVQSLRPEVWKFLLN 387
            |:|..|:..     :|..|:.:.:|..|...:|.::.|.. |...|...|:...:|.|.||||..
Mouse     8 NSLSARRSATFILEKRNPPIDKAEWDSFFDENGHLAKSRDFICINILERGLHPFVRTEAWKFLTG 72

  Fly   388 YYLWSDTHVERI----ERRKQKSIEYYNMKAQWLAMTTTQEANFCG-YRERKCQIEKDVKRTDRS 447
            ||.|..:..||:    .||:.     ||...|..........|..| :.|.:..|..|::|
Mouse    73 YYSWQSSRDERLMVDSNRRRN-----YNSLCQMYEKIQPLLENLHGNFTETRNNIAYDIQR---- 128

  Fly   448 LQFFAGEDNPNL-----TLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQV-NEVDTFWCFVGF 506
              .:..:...|:     .|.:.:|::||. |....|.:|..:::. :.::.| ::.:|||.|..|
Mouse   129 --LYDKDPLGNVLIDKKKLEKTLLLSYVC-NTKAEYQRGFHEMVM-LFQLMVEHDHETFWLFQFF 189

  Fly   507 MELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNS-ED 570
            ::....:..|: .|:......:..||...:.....:::...|..:...|.|..:.::|...: :|
Mouse   190 LQKTEHSCVIN-IGVGKNLDMLNSLITLLDPEFAEHLKGKGSGAVQSLFPWFCLCFQRAFKTFDD 253

  Fly   571 VLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEG 635
            |.:|||.|.|..||.||.:|.:.::|.......:........||...|.|. ::|..:.:..|..
Mouse   254 VWRLWEVLLTGKPCRNFQVLVAYSMLQMVREQALLECMSGDAILMACNNLI-DLDADELISAACV 317

  Fly   636 IYLQLKGSETLPNDIRSII 654
            :|.:|...| :|..::..:
Mouse   318 VYSELMQKE-VPQPLKEFL 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	58/240 (24%)
Tbc1d21	NP_083130.1	TBC	62..287	CDD:214540	57/238 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820