DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d9

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001104774.1	Gene:	Tbc1d9 / 71310	MGIID:	1918560	Length:	1264	Species:	Mus musculus

Alignment Length:	664	Identity:	128/664 - (19%)
Similarity:	233/664 - (35%)	Gaps:	214/664 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   172 VHSEFFFQHGNADLFVRSMRDQHLIENAETSRSGGEVYAILTTENQKLKKTFA---ELDIGQIKA 233
            ::..|......|::.:|.:.|.   |..|..||      :...:.:..||..|   :|| .:.|:
Mouse   238 INETFKLMEQLANIAMRQLLDN---EGFEQDRS------LPKLKKKSPKKVSALKRDLD-ARAKS 292

  Fly   234 S------QLPRES----------WLPNKLAGILG----------------NIPDYVQP------- 259
            .      :||::.          |.|.....|||                |:...:.|
Mouse   293 ERYRALFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIV 357

  Fly   260 -----------PFQRSPKSRPGVLISG--DR------------QTSPDNYQIIGLSGSTNSA--- 296
                       |...|.::|...|.:.  ||            ||:...|.....|||.||:
Mouse   358 EKADSCSVLPSPLSISTRNRMTFLFANLKDRDFLVQRISDFLQQTTSRIYSDKEFSGSCNSSDDE 422

  Fly   297 ----CSSNGQSRGGSAEKSPADSELE-TLNAQDEKIVNNLPD----------RQRVERGHPLTET 346
                .||...|....:..|.||.|.. .||.      |::|.          |:..|..:|....
Mouse   423 VYSRPSSLVSSSPQRSTSSDADGERPFNLNG------NSVPTATQTLMTMYRRRSPEEFNPKLAK 481

  Fly   347 QWLEFQTPDGRISD---------SARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERR 402
            ::|:.|......::         :.:.:||:.: |:.:|:|.|:|..|........||....|..
Mouse   482 EFLKEQAWKIHFAEYGQGICMYRTEKTRELVLK-GIPESMRGELWLLLSGAINEKATHPGYYEGL 545

  Fly   403 KQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILM 467
            .:||:..||:..:                    :||:|:.|:......|..|  ..:..|:.:|.
Mouse   546 VEKSMGKYNLATE--------------------EIERDLHRSLPEHPAFQNE--MGIAALRRVLT 588

  Fly   468 TYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLI 532
            .|...|.::||.|.| :::..:|.:...|.:.||..|...|                    |.|.
Mouse   589 AYAFRNPNIGYCQAM-NIVTSVLLLYAKEEEAFWLLVALCE--------------------RMLP 632

  Fly   533 EFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECL------------WTRLPCP 585
            ::.|..:...:    .|...|          .||..:.|.:|::|:            |
Mouse   633 DYYNTRVVGAL----VDQGVF----------EELARDYVPQLYDCMQDLGVISTISLSW------ 677

  Fly   586 NFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELS-----GNIDVQKTLQVAE--------GIY 637
             |..|| ::::..|:.|::...: |.|.:|.:.:|:     .|:|  |.|...:        |.|
Mouse   678 -FLTLF-LSVMPFESAVVVVDCF-FYEGIKVIFQLALAVLDANVD--KLLNCKDDGEAMTVLGRY 737

  Fly   638 LQ--LKGSETLP--NDIRSIIGEPLLPAAAGE--EIDGGMVDEEPTYSDDGFDELVKELTPEEKV 696
            |.  .....|||  ..:.|::.:.:.|..|.:  .:.|...::..|...|    |::::..::::
Mouse   738 LDSVTNKDSTLPPIPHLHSLLSDDVGPYPAVDIFRLIGTSYEKFGTIRAD----LIEQMRFKQRL 798

  Fly   697 RQQALLEEACERSL 710
            :....||:..:|::
Mouse   799 KVIQTLEDTTKRNV 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	3/18 (17%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	47/240 (20%)
Tbc1d9	NP_001104774.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	2/16 (13%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	13/94 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	410..456		15/51 (29%)
		TBC	512..722	CDD:214540	56/278 (20%)
		EFh	<893..923	CDD:298682
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1119..1162
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900