DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d15

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006514020.1	Gene:	Tbc1d15 / 66687	MGIID:	1913937	Length:	688	Species:	Mus musculus

Alignment Length:	720	Identity:	230/720 - (31%)
Similarity:	346/720 - (48%)	Gaps:	141/720 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 TGNILFTHDGVLLKKASAE-HIADLNTSGSLSLVEYSRSIAEMPRRRLLLEWQPND------SIM 95
            :|.|::..:||.:..:..: :..|...||.|.::|....:        :::|:|.|      ||:
Mouse     8 SGKIIYEQEGVYIHSSCGKANDQDSLISGILRVLEKDAEV--------IVDWRPLDDALDSSSIL 64

  Fly    96 IA---------------------DDSQD--QGDWALVDRISGRTRTTSECRAFNTRPI---EPSG 134
            .|                     .|.|.  :.:|.:|..:|           |..:|.   :..|
Mouse    65 CAGKDSSSVVEWTQAPKERAHRGSDQQSSYEAEWDMVTTVS-----------FKKKPHTNGDAPG 118

  Fly   135 GATTRSR-VMRAQLEDLSSVEVRHRG---QTIRFMRKG---ANGVHSEFFFQHGNADLFVRSMRD 192
            ....:|: .....|.||.||:....|   ..:.|..|.   ...:|    |..|::.|.:.|: :
Mouse   119 HRNGKSKWSFLFSLADLKSVKQSKEGMGWSYLVFCLKDDVMLPALH----FHQGDSKLLIESL-E 178

  Fly   193 QHLI--ENAETSRSGGEVYAILTTENQKLKKTFAEL----DIGQIKASQLPRES--WLPNKLAGI 249
            ::::  |:.:.||:     .::..:|:.|.::|..|    ..|.|:|..|.|..  |
Mouse   179 KYVVLCESPQDSRT-----LLVNCQNKSLSQSFENLLDEPAYGLIQAGLLDRRKLLW-------- 230

  Fly   250 LGNIPDYVQPPFQRSPKSRPGVLISGDRQTSPDNY--QIIGLSGSTNSACSSNGQSRGGSAEKSP 312
                                  .|...|:...|.|  .::|.|..||....|...|...:.::.|
Mouse   231 ----------------------AIHHWRKIKKDPYTATMVGFSKVTNYIFDSLRGSDPSTHQRPP 273

  Fly   313 ADSELE----------TLNAQDE---KIVN--NLPDRQRVERGHPLTETQWLEFQTPDGRISDSA 362
              ||:.          .:|.|:|   :::.  :|.:|..|:|..|::..:|.:...|:||:....
Mouse   274 --SEMADFLSDAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWNKSLDPEGRLVAVE 336

  Fly   363 RIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANF 427
            .:|:.|||||:..|||.:.|||||.|:.|..|..||.:.:|||:.||:.||.||.:::..||...
Mouse   337 SMKQKIFRGGLSHSLRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSVSEAQEKRN 401

  Fly   428 CGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEI 492
            ...|:.:..|||||.||||:.:|:.|:|||.|.||..|||||.||:|||||||||||||:|:|.:
Mouse   402 SRLRDYRSLIEKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYV 466

  Fly   493 QVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRW 557
            ..||||.||||..:|:.:..||:....|||||..|:..|:...::...:|:.|.||..:||||||
Mouse   467 MENEVDAFWCFASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRW 531

  Fly   558 LLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSG 622
            ||:.:|||.:..|:|:|||.:||.|||.|||||...|||:.|.:.|:...|.|.|||||:||||.
Mouse   532 LLIRFKREFSFLDILRLWEVMWTELPCKNFHLLLCCAILESEKQQIMAKHYGFNEILKHINELSM 596

  Fly   623 NIDVQKTLQVAEGIYLQLKGSETLPNDIRSIIGEPLLPAAAGEEIDGGMVDEEPTYSDDGFDELV 687
            .|||:..|..||.|.||:...:.||..:..|:               |:.|.|.|..|...||.|
Mouse   597 KIDVEDILCKAEAISLQMAQCKELPQAVCEIL---------------GLQDSEITTPDSDTDENV 646

  Fly   688 KELTP 692
            ....|
Mouse   647 GSPCP 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	37/192 (19%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	119/228 (52%)
Tbc1d15	XP_006514020.1	DUF3548	10..211	CDD:371881	43/229 (19%)
Tbc1d15	XP_006514020.1	TBC	343..578	CDD:214540	120/234 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2080
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11249
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	1	1.000	-	-		FOG0002107
OrthoInspector	1	1.000	-	-		otm43582
orthoMCL	1	0.900	-	-		OOG6_101355
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2140
SonicParanoid	1	1.000	-	-		X1395
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.810