DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and TBC1D15

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006719627.1	Gene:	TBC1D15 / 64786	HGNCID:	25694	Length:	699	Species:	Homo sapiens

Alignment Length:	710	Identity:	233/710 - (32%)
Similarity:	355/710 - (50%)	Gaps:	108/710 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 NLPQQGTGNILFTHDGVLLKKASAE-HIADLNTSGSLSLVEYSRSIAEMPRRRLLLEWQPND--- 92
            :|.:.|...|::..:||.:..:..: :..|...||.|.::|....:        :::|:|.|
Human    10 SLLEYGRSMIIYEQEGVYIHSSCGKTNDQDGLISGILRVLEKDAEV--------IVDWRPLDDAL 66

  Fly    93 ---SIMIA-DDSQDQGDWALVDRISGR---------------TRTTSECRAFNTRPIEPS--GGA 136
               ||:.| .||....:|....:..|.               ..|.|..|..:|....||  .|.
Human    67 DSSSILYARKDSSSVVEWTQAPKERGHRGSEHLNSYEAEWDMVNTVSFKRKPHTNGDAPSHRNGK 131

  Fly   137 TTRSRVMRAQLEDLSSVEVRHRG---QTIRFMRKGANGVHSEFFFQHGNADLFVRSMRDQHLI-- 196
            :..|.:.  .|.||.|::....|   ..:.|..|. :.|.....|..|::.|.:.|: :::::
Human   132 SKWSFLF--SLTDLKSIKQNKEGMGWSYLVFCLKD-DVVLPALHFHQGDSKLLIESL-EKYVVLC 192

  Fly   197 ENAETSRSGGEVYAILTTENQKLKKTFAEL----DIGQIKASQLPRESWLPNKLAGILGNIPDYV 257
            |:.:..|:     .::..:|:.|.::|..|    ..|.|:|..|.|     .||...:.:.....
Human   193 ESPQDKRT-----LLVNCQNKSLSQSFENLLDEPAYGLIQAGLLDR-----RKLLWAIHHWKKIK 247

  Fly   258 QPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELE---- 318
            :.|:..:                     :||.|..||....|...|...:.::.|  ||:.
Human   248 KDPYTAT---------------------MIGFSKVTNYIFDSLRGSDPSTHQRPP--SEMADFLS 289

  Fly   319 ------TLNAQDE---KIVN--NLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGG 372
                  .:|.|:|   :::.  :|.:|..|:|..|::..:|.:....:|||.:...:|::|||||
Human   290 DAIPGLKINQQEEPGFEVITRIDLGERPVVQRREPVSLEEWTKNIDSEGRILNVDNMKQMIFRGG 354

  Fly   373 VVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQI 437
            :..:||.:.|||||.|:.|..|..||.:.:|||:.||:.||.||.:::..||......|:.:..|
Human   355 LSHALRKQAWKFLLGYFPWDSTKEERTQLQKQKTDEYFRMKLQWKSISQEQEKRNSRLRDYRSLI 419

  Fly   438 EKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWC 502
            ||||.||||:.:|:.|:|||.|.||..|||||.||:|||||||||||||:|:|.:..||||.|||
Human   420 EKDVNRTDRTNKFYEGQDNPGLILLHDILMTYCMYDFDLGYVQGMSDLLSPLLYVMENEVDAFWC 484

  Fly   503 FVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELN 567
            |..:|:.:..||:....|||||..|:..|:...::...:|:.|.||..:||||||||:.:|||.:
Human   485 FASYMDQMHQNFEEQMQGMKTQLIQLSTLLRLLDSGFCSYLESQDSGYLYFCFRWLLIRFKREFS 549

  Fly   568 SEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQV 632
            ..|:|:|||.:||.|||.|||||...|||:.|.:.|::..|.|.|||||:||||..|||:..|..
Human   550 FLDILRLWEVMWTELPCTNFHLLLCCAILESEKQQIMEKHYGFNEILKHINELSMKIDVEDILCK 614

  Fly   633 AEGIYLQLKGSETLPNDIRSIIGEPLLPAAAGEEIDGGMVDEEPTYSDDGFDELVKELTP 692
            ||.|.||:...:.||..:..|:|      ..|.|:      ..|. ||.|.||.| .:||
Human   615 AEAISLQMVKCKELPQAVCEILG------LQGSEV------TTPD-SDVGEDENV-VMTP 660

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	39/181 (22%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	118/228 (52%)
TBC1D15	XP_006719627.1	DUF3548	19..227	CDD:192931	45/224 (20%)
TBC1D15	XP_006719627.1	TBC	351..586	CDD:214540	119/234 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	250	1.000	Domainoid score	I2116
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11249
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	1	1.000	-	-		FOG0002107
OrthoInspector	1	1.000	-	-		otm41532
orthoMCL	1	0.900	-	-		OOG6_101355
Panther	1	1.100	-	-	O	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2140
SonicParanoid	1	1.000	-	-		X1395
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.810