DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and rabgap1l2

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_694092.1	Gene:	rabgap1l2 / 565728	ZFINID:	ZDB-GENE-070912-414	Length:	320	Species:	Danio rerio

Alignment Length:	319	Identity:	64/319 - (20%)
Similarity:	110/319 - (34%)	Gaps:	112/319 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 QVQLGVFNES----QLSSVEED------VQNLPQQGTGNILFTHDGVLLKKASAEHIADLNTSGS 66
            :|.:.|..:|    |:|  ||:      |::||:|             :..:..:.:.|......
Zfish     4 EVSIAVAYDSHIIDQMS--EEEILASLVVESLPKQ-------------VVPSKKQKLRDNQEQPE 53

  Fly    67 LSLVEYSRSIAEMPRRRLLLEWQPNDSI-------MIA-----DDSQDQGDWALVDRISGRTRTT 119
            ..|.:|.|...::....|.|| |.||.:       .||     |.::||     ||.:   |:..
Zfish    54 DPLDKYERENRKLQETSLRLE-QENDDLAQKLVTSKIALRNALDQTEDQ-----VDEL---TKEL 109

  Fly   120 SECRAFNTRPIEPSGG----ATTRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQH 180
            |:.:.......|...|    |:....:.|.:|:...| :::.....|...::..:.::::...|.
Zfish   110 SKVKQLLVVTEEEKRGKEEEASQLKEMFRKELDKAES-DIKRSNSIIADYKQICSQLNTKLENQK 173

  Fly   181 GNAD---LFVRS-----------------------MRDQHLIENAETS----------------- 202
            ..||   .|::|                       ..|:...:.|:||
Zfish   174 EEADKNLAFIKSKLQECERCSRIFSVDGSIESCSESEDRSAQDEAKTSLREQVKELEKELAQTKL 238

  Fly   203 ---RSGGEVY------AILTTE-----NQKLKKT---FAELDIGQIKASQLPRESWLPN 244
               .|..::.      |:|.||     |..||||   |.....||..:||.. .:|.||
Zfish   239 QMVESKCKIQELEHQKAVLMTELQAAKNTWLKKTLDSFKTAASGQQSSSQTD-SAWSPN 296

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	31/195 (16%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540
rabgap1l2	XP_694092.1	Smc	<56..>265	CDD:224117	39/218 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900