DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and usp6nl

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_005164934.1	Gene:	usp6nl / 561983	ZFINID:	ZDB-GENE-041210-192	Length:	849	Species:	Danio rerio

Alignment Length:	429	Identity:	96/429 - (22%)
Similarity:	164/429 - (38%)	Gaps:	106/429 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 ILGNIPDYVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRG-GSAEKSP 312
            :|..:.:.|.|..:|          :|.|.|:.|:.|...:......|.......:| ..||..|
Zfish     3 VLQIVKELVSPSRRR----------AGSRFTASDSEQDAAVKLEQERAEILAKYDKGKEKAEVEP 57

  Fly   313 -ADSELETLNAQD--------EKIVNNLPDRQR---VERGHPLTETQWLEFQTPDGRISDSARIK 365
             .::..|...|.|        |.:.:.:.::|:   |||     .|:||:......:..:|.::.
Zfish    58 WEETNFELYKAVDRFGFLHEGELVYDIVEEKQKQLEVER-----TTKWLKMLKSWEKYKNSDKLV 117

  Fly   366 ELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGY 430
            ..|::|..:| ||.:||..||:        :.:|:..|:...|...::|:.|:....
Zfish   118 RRIYKGIPLQ-LRGQVWCLLLD--------IPKIKEEKKDFYEKLKIRARGLSPDVR-------- 165

  Fly   431 RERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVN 495
                 ||:.||.||.|:...|....:.....|..:|..|.:||.::||.||||.:.| :|.|.:|
Zfish   166 -----QIDLDVNRTYRNHIMFMHRYDVKQQDLFHVLTAYSVYNTEVGYCQGMSQITA-LLLIYMN 224

  Fly   496 EVDTFWCFVGFMELVFTNFDIDQAGMK--------TQFAQIRRLIEFANAPLFNYM---RSH-DS 548
            |.|.||..|..:           :|.:        ..|.::.|..|..:..|...|   :.| |:
Zfish   225 EEDAFWALVKLL-----------SGQRHTMHGFFVPGFPKLMRFQEHHDRILQKMMPKLKQHLDN 278

  Fly   549 DNMY---FCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEF 610
            ..:|   :..:|                .::|...|.|......::.:.||:.| ||:....|..
Zfish   279 QEVYTSLYTMKW----------------FFQCFLDRTPFTLTLRIWDIYILEGE-RVLTAMSYTI 326

  Fly   611 TEILKHVNELSGNIDVQKTLQVAEGIYLQLKGSETLPND 649
            .::.|.........::.|.|||            ||.||
Zfish   327 LKLHKKTLLKLSMEELVKFLQV------------TLSND 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	56/243 (23%)
usp6nl	XP_005164934.1	TBC	120..326	CDD:214540	61/256 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810