DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and tbc1d2

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_689604.6	Gene:	tbc1d2 / 561110	ZFINID:	ZDB-GENE-140106-100	Length:	926	Species:	Danio rerio

Alignment Length:	708	Identity:	134/708 - (18%)
Similarity:	254/708 - (35%)	Gaps:	208/708 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ESVRYDRCHQVQLGVFNESQLSSVEEDVQNLPQQGTGNILFTHDGVLLKKASAEHIADLNTSGSL 67
            |.:|:......:|.|    ||.:::::.:||.:.     |...|         ||:|:|..|
Zfish   361 ELLRHGERRAAELRV----QLEALQQENENLRRD-----LTQRD---------EHVAELQNS--- 404

  Fly    68 SLVEYSRSIAEMPRRRLLLEWQPNDSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEP 132
                          .:|||:             ::|....::.::|.:..|..|.:.: |..:|
Zfish   405 --------------IQLLLQ-------------KNQTKQEVILKLSEKLTTCGEDQQY-TNGLE- 440

  Fly   133 SGGATTRSRVM-RAQL-EDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFVRSM----- 190
              ..|.|...| ..|| :||.:..:::                     |:.|::::..:|
Zfish   441 --SETFRQMTMENEQLKDDLKAYNIQN---------------------QYLNSEIYQLTMLWRKS 482

  Fly   191 --RDQHLIENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQ--LPRESWLPNKLAGILG 251
              |::.||...          |:|...|.:::..:..: :.:::.||  .|.:....||:
Zfish   483 SEREKSLIVKC----------AVLEANNCQMESRYLGI-LQKLQESQELNPEQREAVNKM----- 531

  Fly   252 NIPDYVQPPFQRSPKSRP-------GVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAE 309
             :.|.||.....:.|..|       |..|:.|       |::                      |
Zfish   532 -LKDAVQADLNNAIKLNPISDYDEYGFRIAVD-------YKV----------------------E 566

  Fly   310 KSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVV 374
            .....::::.|..:.:.::|     |....|..|.....|.|..|:|.::.||.:|.|: |.|:.
Zfish   567 DLKLLAKIQALEFRSQNLLN-----QEECDGPLLARCAQLLFGRPEGELTSSAEMKGLL-RTGLP 625

  Fly   375 QSLRPEVWKFLLNYYLWS--DTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQI 437
            ...|..||:|::.....|  :.|.:|.....:||....::..:                    ||
Zfish   626 HEYRVRVWRFMIQTRTKSLRERHPDRYHELCEKSRSSPHLVPR--------------------QI 670

  Fly   438 EKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWC 502
            :.|:.||..|.:.|:...:|.:..|:.:|..:..:|..:|||||::.|.|..|.:...|.|.|||
Zfish   671 QLDLDRTLTSNKHFSPPTSPLIQKLERVLQAFSWHNPTIGYVQGLNRLAAIALLVLQEEADAFWC 735

  Fly   503 FVGFMELVF--TNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRE 565
            .|..:|.:.  ..|..|..|.:.....::.|:......|..::.:...|.......|.||.:...
Zfish   736 LVVIVEHIMPPNYFTKDLVGCQADQRVLKDLMLEKLPRLTAHLEALKVDISLITVEWFLVLFVES 800

  Fly   566 LNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQ-----YEFTEIL----------- 614
            |.:..:.|:|:.|........|.  :::|:.......|:..|     |::..|.
Zfish   801 LPTRILFKVWDALLYEGSKVIFR--YALALFKYREEAILKIQDSVEMYQYLRIFPNTIADGRKLT 863

  Fly   615 --------------------KHVNELSGNIDVQKTLQ---VAEGIYLQLKGSETLPND 649
                                .|:..|...|...:.||   .||.::.:.|..::|.:|
Zfish   864 SIAFNDMNPLRMRLIQNRRAAHLERLHAEIKELENLQKAYKAERVHCKDKKLDSLASD 921

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	26/162 (16%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	52/232 (22%)
tbc1d2	XP_689604.6	PH	56..146	CDD:278594
		PH_TBC1D2A	57..153	CDD:269966
		TBC	621..837	CDD:214540	52/237 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810