DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and tbc1d14

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_005166496.1	Gene:	tbc1d14 / 557744	ZFINID:	ZDB-GENE-030131-6136	Length:	711	Species:	Danio rerio

Alignment Length:	669	Identity:	135/669 - (20%)
Similarity:	246/669 - (36%)	Gaps:	141/669 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 DGVLLKK-------------------ASAEHIADLNTSGSLSLVEYSRSIAEMPRRRLLLEWQPN 91
            ||.|||.                   :||.....||.|..:|:...|....|.
Zfish   127 DGSLLKSSTFPRCDFDLVRHYGPSGLSSAAGKGTLNRSDDISVCSVSSLSTEF------------ 179

  Fly    92 DSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTRSRVMRAQLEDLSSVEVR 156
             |..::..::|..|:.:          |||..|.          .|..:..:..:.:...|..:.
Zfish   180 -STTLSVSNEDFLDFMV----------TSESSAV----------VTFENEDVLHRFDSSLSAPID 223

  Fly   157 HRGQTIRFMRK--GANGVH----------SEFFFQHGNADLFVRSMRDQHLIENAETSRSGGEVY 209
            ..|:.....|:  |.:|.|          :.||    |..||.:.|:|...:|...  ..|.:::
Zfish   224 LHGKLSSPQRQPVGVSGAHEARPKRLGPLASFF----NRGLFAKRMKDTGALEGQR--EPGWKLF 282

  Fly   210 A------ILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSPKSR 268
            .      :.|.:::||:|.: |...|....|..|:::                |:......|.|.
Zfish   283 GKVPHKDLPTKDSRKLQKEY-ERRSGHTSNSTSPKKN----------------VRKNLDFEPLST 330

  Fly   269 PGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETL-NAQDEKIVNNLP 332
            ..:::    :..|.|..         :......|......|:..|.::...| :||..|  ..|.
Zfish   331 TALIL----ENRPANLP---------AKPEEEAQKHRQQYEEMVAQAKKRELKDAQKRK--KQLE 380

  Fly   333 DRQRVERGHPLTETQWLEFQTPDGR-ISDSARIKELIFRGGVVQSLRPEVWKFLLNYYL--WSDT 394
            ||.::|.........|.:...|:.: :..|.|:::|.:: |:..|:|.:||...:...|  ..:.
Zfish   381 DRCKLEESIGNAALTWSQEILPNWQSMCSSKRVRDLWWQ-GLPPSVRGKVWSLAIGNELNITDEL 444

  Fly   395 HVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIE---KDVKRTDRSLQFFAGEDN 456
            :...:.|.|:|   :....|...|:.|..|.....:.:|:..:|   .|:.||..:|..|. :..
Zfish   445 YDICLARAKEK---WNAFVAPTAAVETESEDAGLSHADREASLELIKLDISRTFPNLCIFQ-KGG 505

  Fly   457 PNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFM----ELVFTNFDID 517
            |...:|..||..|..|..|:||||||| .:|.:|.:.::..|.|..|...:    ::.|  :.:|
Zfish   506 PYHDVLHSILGAYTCYRPDVGYVQGMS-FIAAVLILNLDTADAFIAFANLLNKPCQMAF--YRVD 567

  Fly   518 QAGMKTQFAQIRRLIEFANAP-LFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTR 581
            .:.|.|.||......| .|.| ||.:.::::..:..:...|:...|.:.|..:...::|:..
Zfish   568 HSLMLTYFAAFEVFFE-ENLPKLFAHFKNNNLSSDIYLIDWIFTLYSKSLPLDIACRVWDVF--- 628

  Fly   582 LPC-PNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQLKGSET 645
              | .....||..|:........|.:..:|..|.:.:..|...|..::.......|.:..| ::.
Zfish   629 --CRDGEEFLFRTALGILRLYEDILTHMDFIHIAQFLTRLPDYISAEEIFSSITTINMNSK-NKK 690

  Fly   646 LPNDIRSI-----IGEPLL 659
            .|..::::     .|.|||
Zfish   691 WPQVLQALQKGQDRGSPLL 709

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	32/175 (18%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	58/239 (24%)
tbc1d14	XP_005166496.1	COG5210	293..656	CDD:227535	87/408 (21%)
tbc1d14	XP_005166496.1	RabGAP-TBC	485..651	CDD:278964	44/175 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810