DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and tbc1d25

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001121708.1	Gene:	tbc1d25 / 556338	ZFINID:	ZDB-GENE-041111-25	Length:	863	Species:	Danio rerio

Alignment Length:	536	Identity:	141/536 - (26%)
Similarity:	238/536 - (44%)	Gaps:	118/536 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   193 QHLIENA--------------ETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRESWLP 243
            ||::..|              ...|:|.|||..|.::        .:||...:.|::
Zfish    41 QHILIRAFELNGKRNFGISYLSRDRAGVEVYVSLLSD--------WDLDAAFVSAAK-------- 89

  Fly   244 NKLAGILGNIPDYVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIG---LSGSTNSACSSNGQSRG 305
                       .|:|......|.....||...|..:..|   :||   |.|...|..|:
Zfish    90 -----------PYLQLKMDIKPSEDSPVLEDWDIISPKD---VIGSDQLQGEKRSLASA------ 134

  Fly   306 GSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGH-------PLTETQWLEFQTPDGRISDSAR 363
                   |....::|.:|..:.::.:........|.       ||::.::..:....|::|....
Zfish   135 -------ALPFTQSLLSQVGRTLSRVQQALSWSYGEEVKPFKPPLSDAEFHNYLNSQGQLSRPEE 192

  Fly   364 IKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFC 428
            ::..|:.|||..|||..||::|||.|....|..||::..|:|:.||..:|::|.|..:::|..|.
Zfish   193 LRLRIYHGGVESSLRKVVWRYLLNVYPDGLTGQERMDYMKRKTREYDQLKSEWTARVSSEELEFI 257

  Fly   429 GYRERKCQIEKDVKRTDRSLQFFAG-EDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEI 492
                 :..:.|||.||||:..::|| ||:|:||.|..:|.|:.:.:..:.|.|||||:.:|||.:
Zfish   258 -----RGNVLKDVLRTDRAHPYYAGSEDSPHLTALTDLLTTFAITHPQVSYCQGMSDIASPILAV 317

  Fly   493 QVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRW 557
            ..||...|.||.|.|:.:..||..|...|..:|..::.|:::::...::|:.|..:|:::||:||
Zfish   318 MDNEAHAFICFCGIMKRLEGNFRPDGQLMSIKFQHLKLLLQYSDPEFYSYLVSKGADDLFFCYRW 382

  Fly   558 LLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRV-IIDSQYEFTEILKHVNELS 621
            ||:..|||...:|.|::.|..|:.|| |:          ..||.| ::...:|..:     ::.|
Zfish   383 LLLELKREFAFDDALRMLEVTWSSLP-PD----------PPETEVELLGPAFEADQ-----SDGS 431

  Fly   622 GNIDVQKTLQVAEGIYLQLKGSETLPNDIRSIIGEPLLPAAAGEEIDG--GMVDEE---PTYSDD 681
            .|:|:::         ::.|.:|      |......|.|:.  ||.||  .:|.||   |....:
Zfish   432 HNVDMEE---------MEEKQTE------RQRRRHMLRPSR--EEADGERNLVMEEERGPRKEGE 479

  Fly   682 GFDELVKELTPEEKVR 697
            |      |...|..||
Zfish   480 G------EYDVESMVR 489

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	82/229 (36%)
tbc1d25	NP_001121708.1	TBC	198..420	CDD:214540	85/237 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.820