DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and rabgap1l

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_021325262.1	Gene:	rabgap1l / 555272	ZFINID:	ZDB-GENE-050208-389	Length:	1069	Species:	Danio rerio

Alignment Length:	680	Identity:	140/680 - (20%)
Similarity:	249/680 - (36%)	Gaps:	156/680 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   129 PIEPSGGATTRSRVMRAQLED----LSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFV-- 187
            |:.|.....|.|..:..:.:|    .|.|. :.|.:....:|:|.....|....|..|.:|.:
Zfish   295 PLSPDSDVFTFSVSLEVREDDGKGNFSPVP-KDRDKYYFKLRQGVQKKVSVVVQQLNNKELVIER 358

  Fly   188 ---------RSMR--DQHLIENAETSRSG-GEVYAI-------------LTTENQKLKKTFAELD 227
                     :.:|  |.||::.....::. |:.|.|             |..:..|.|:.:..:.
Zfish   359 CFGMLLSPGQKVRNSDMHLLDMESMGKNADGKAYVITGIWNPNTPAFQPLNEDTPKDKQVYMTVA 423

  Fly   228 IGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQR----SPKSRPGV----LISGDRQTSPDN- 283
            :..:....:....:|...|.        .|.|..:|    |.|:....    |..|..:.|.|:
Zfish   424 VDLVVTEVVEPVRFLMEALV--------RVYPANERFWYFSRKAFCETFYLKLKQGSVKGSQDDM 480

  Fly   284 -YQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQ 347
             |:::.|...:.....:.|:.:..:.|:.|.:.....:::....:..:.|::.....|..|...|
Zfish   481 MYEVVSLEKHSECGSQARGRLQSPTEEEEPEEDSDSEISSGTGDVSKDCPEKILESWGGILNRWQ 545

  Fly   348 WLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNM 412
            ......|.|.   ||.:|.     |:.::||.|||:.|      |..|      ..|..:|.|.:
Zfish   546 GNLLTRPKGL---SALVKP-----GIPEALRAEVWQLL------SGCH------NDQALLEQYRI 590

  Fly   413 KAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLG 477
                  :.|.:.|       ::..|.:|:.||..:..:|..........|..|...|.:|:.::|
Zfish   591 ------LITKESA-------QEAVITRDIHRTFPAHDYFKDSGGDGQDSLYKICKAYSVYDEEIG 642

  Fly   478 YVQGMSDLLAPILEIQVNEVDTFWCFV------GFMELVFTNFDIDQAGMKTQFAQIRRLIEFAN 536
            |.||.| .||.:|.:.:.|...|...|      |..||...||:    .:..:|.|:.||::...
Zfish   643 YCQGQS-FLAAVLLLHMPEEQAFCVLVKIMFNYGLRELYRNNFE----DLHCKFYQLERLLQELL 702

  Fly   537 APLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQET- 600
            ..|:::.:..:.:...:..:|.|..:..:.....|..:.:.|.    |...:::|:||:...:|
Zfish   703 PDLWSHFQELNLEAHMYASQWFLTLFTAKFPLCMVFHITDLLL----CEGLNIIFNVALALLKTS 763

  Fly   601 ----------------RVIIDSQYEFTEILKHVNELSGNIDV-QKTLQVAEGIYLQLKGSETLPN 648
                            ||.:..:|...|..:.:.|.:.||.| .|.|:..|..|..|:.|:....
Zfish   764 KEDLLQADFEGALKFFRVQLPKRYRAAENARRLMEQACNIKVPTKKLKKFEKEYQSLRESQLQQE 828

  Fly   649 DIRSIIGEPL---------LPAAAG--EEIDGGMVDEEPT----------YSDDGFDELVKEL-- 690
            |       |:         |..|:.  |:.:..:..|..|          .::|..|.|.|||
Zfish   829 D-------PIDRYQRENRRLQEASMRLEQENDDLAHELVTSKIALRNDLDQAEDKADVLNKELLN 886

  Fly   691 -------TPEEKVRQQ---ALLEEACERSL 710
                   |.|||.||:   |.|:|...|.|
Zfish   887 TKQRLVETEEEKRRQEEETAQLKEVFRREL 916

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	14/76 (18%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	52/234 (22%)
rabgap1l	XP_021325262.1	PTB_Rab6GAP	157..285	CDD:269922
		DUF3694	319..450	CDD:315198	23/139 (17%)
		RabGAP-TBC	565..768	CDD:306939	52/236 (22%)
		SMC_N	784..>1042	CDD:330553	36/140 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810