DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and si:dkeyp-19e1.3

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_005170766.1	Gene:	si:dkeyp-19e1.3 / 553000	ZFINID:	ZDB-GENE-081104-56	Length:	736	Species:	Danio rerio

Alignment Length:	444	Identity:	99/444 - (22%)
Similarity:	172/444 - (38%)	Gaps:	104/444 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   314 DSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLR 378
            :.||.|..|.:||.     ..|.:||     |.:|::......:..:|.::.:.::: |:...||
Zfish    52 EEELPTPTAVEEKY-----KLQEMER-----EEKWIKMVKKWEKYHNSEKMMKRVYK-GIPLKLR 105

  Fly   379 PEVWKFLLNYYLWSDTHVERIERRKQKSI-EYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVK 442
            .:.|..||:           :|:.||.:. :|..||.|....:|          |.| ||:.||.
Zfish   106 GQAWALLLD-----------VEKVKQANFRKYEKMKEQAKRYST----------EIK-QIDLDVN 148

  Fly   443 RTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFM 507
            ||.|:...|..........|..:|..|.:||.::.|.||||. :|.||.:.:||.|.||.    :
Zfish   149 RTFRNHIMFMERFGVKQQALFHVLAAYSVYNTEVSYCQGMSQ-IAAILLMYMNEEDAFWA----L 208

  Fly   508 ELVFTNFDIDQAGM------KTQFAQIR--RLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKR 564
            ..:.||......|.      |....|:.  :::....:.|.|::.........:..:|.|
Zfish   209 SQLLTNQKHAMHGFFIPGFPKLHRFQVHHDKILSKLLSKLRNHLEKEQMSTGIYTTKWFL----- 268

  Fly   565 ELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEI-LKHVNELSGNIDVQK 628
                       :|...|.|......|:.:.||:.| :|:....|...:: .||:.:||.. |:::
Zfish   269 -----------QCFIDRTPFTLTLRLWDIYILEGE-KVLTAMAYTLLKLHKKHLLKLSLE-DLRE 320

  Fly   629 TLQ--------VAEGI---YLQLKGSE------TLP-----NDIRSI-IGE-------------- 656
            .||        :::.:   :||...||      .||     ::...| :||
Zfish   321 FLQERTASSFNMSDDVVIEHLQSSMSELRRMKLDLPPPGKGDEFPKIPLGEERLIELLSVIQTER 385

  Fly   657 -PLLPAAAGEEIDGGMVDEEPTYSDDGFDELVKELTPEEKVRQQALLEEACERS 709
             ||..||...:....:..|:.|..:...::.:..:|......||:.|..:...|
Zfish   386 VPLPSAAHNNQAASKLQTEDTTSHNQCSNKPIPRITSSSSFSQQSQLPSSSSLS 439

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	57/237 (24%)
si:dkeyp-19e1.3	XP_005170766.1	TBC	96..301	CDD:214540	59/249 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810