Protein Alignment Tbc1d15-17 and rabgap1l

DIOPT Version :9

• Sequence 1: NP_001259806.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001361730.1
• Gene: rabgap1l / 550007
• XenbaseID: XB-GENE-483580
• Length: 1056
• Species: Xenopus tropicalis
• Alignment Length: 846
• Identity: 145/846 - (17%)
• Similarity: 275/846 - (32%)
• Gaps: 296/846 - (34%)

  Fly     1 MDESVRYDRCHQVQLGVFNESQL-SSVEEDVQNLP------QQGTGNILFTHDGVLLKKASAE-- 56
            |:|.:|.....|      |.:.| .::.|::...|      ..||.|:..|   ::|...|.|
 Frog    52 MEEILRDSEKTQ------NSNMLKETITEELSTFPTASHFSDTGTKNVPLT---LILDPKSTELP 107

  Fly    57 ----------------------HIADLNTSGSLSLVEYSRSIAEMPRR-------RLLLEWQPND 92
                                  ::..:..|...:.:|..|::|.|..:       .|.:...|..
 Frog   108 VQSTTVLSHPPEEESVSFHKLCYLGCMKVSAPRNEIEALRAMASMKAQCIAPITVTLYVPNIPEG 172

  Fly    93 SIMIADDSQDQ-----GDWALVDRISGRTRTTS-ECRAFNTRPIEPSGGATTRSRVMRAQLED-- 149
            |:.|.|.:...     ..:.::..:.||..|:. :|.||..|.:   |....:..|...::::
 Frog   173 SVRIIDQTNKSEIASFPIYKVLFCVRGRDGTSECDCFAFTERDL---GTEEFQIHVFSCEIKEAV 234

  Fly   150 ------------------------------------LSSVEVRHRGQTIRF----------MRKG 168
                                                :.|:||:.......|          ..|.
 Frog   235 SRILYSFFTAFKRSSRQVSDVKDSALPTPDSDVFTFMVSLEVKEDDSKGNFSPVPKDRDKLFFKL 299

  Fly   169 ANGVHSEFFF---QHGNADLFV-----------RSMR--DQHLIENAETSRSG-GEVYAI----- 211
            ..|:..:...   |..|.:|.|           |:::  |.||::.....:|. |:.|.|
 Frog   300 KQGIEKKVVVTIQQVSNKELLVERCFGMLLSPGRNVKNSDMHLLDMESMGKSSDGKAYVITGIWN 364

  Fly   212 --------LTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPP-------- 260
                    |..|..|.|:.:..:.:..:                     :.:.|:|.
 Frog   365 PNIQAFQALNEETPKDKRVYMTVAVDMV---------------------VTEVVEPVRFLLETVV 408

  Fly   261 -----------FQRSP-------KSRPGVLISGDRQTSPDNYQIIGLSGST------NSACSSNG 301
                       |.|..       |.:|    ||:...:...|:::.|...:      .|..|::.
 Frog   409 RVYPTNERFWYFSRKAFTDTFYLKLKP----SGNIGVTDSMYEVVSLQRQSEIEEAPTSPLSASN 469

  Fly   302 QSRGGSAEKSPADSELETLNAQDEKIVNNLPDR------QRVERGHPLTETQWLEFQTPDGRISD 360
            .|.....:....:|:.|..:...: :..:.|::      |.:.:.|.....:      |.|
 Frog   470 LSSPQEEDDPEEESDTELWSGTGD-VSKDCPEQILDCWGQLLVKWHSNLSVK------PKG---- 523

  Fly   361 SARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEA 425
               :..|:.| |:.::||.|||:.|...:            ..|:.::.|.|   .:...:.|::
 Frog   524 ---LSSLVKR-GIPEALRAEVWQLLAGCH------------ENQEMLDKYKM---LVVKDSAQDS 569

  Fly   426 NFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPIL 490
                      .|.:|:.||..:..:|...:......|..:...|.:|:..:||.|||| .||.:|
 Frog   570 ----------VIRRDIHRTFPAHDYFKNTEGDGQESLYKMCKVYSLYDEVIGYCQGMS-FLAAVL 623

  Fly   491 EIQVNEVDTFWCFV------GFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSD 549
            .:.:.|...|...|      .|..|...||:    .:..:|.|:.||::.....|:::..:.:.:
 Frog   624 LLHMPEEQAFCVLVKIMYDYQFRNLYQNNFE----DLHCKFYQLERLLQEQLPDLYSHFVALNLE 684

  Fly   550 NMYFCFRWLLVWYKRELNSEDVLKLWECLWT-RLP-CPNFH-----------LLFSVAILDQET- 600
            ...:..:|.|                 .|:| :.| |..||           ::|.||:...:|
 Frog   685 AHMYASQWFL-----------------SLFTAKFPLCMVFHIMDLLLSEGLSIIFHVALALLKTS 732

  Fly   601 ----------------RVIIDSQYEFTEILKHVNELSGNIDV-QKTLQVAEGIYLQLKGSETLPN 648
                            ||.:..:|...|..:.:.|.:.||.| .|.|:..|..||.::.|:....
 Frog   733 KEDLLQADFEGALKFFRVQLPKRYRAEENARRLMEQACNIKVPTKKLKKFEKEYLAMRESQLQQE 797

  Fly   649 D 649
            |
 Frog   798 D 798

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	37/252 (15%)
		TBC	369..598	CDD:214540	52/247 (21%)
rabgap1l	NP_001361730.1	PTB_Rab6GAP	123..251	CDD:269922	19/130 (15%)
		DUF3694	284..415	CDD:372133	21/151 (14%)
		TBC	528..737	CDD:214540	53/256 (21%)
		Smc	753..>1011	CDD:224117	13/46 (28%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910