DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and Tbc1d5

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_008764990.1	Gene:	Tbc1d5 / 501088	RGDID:	1561626	Length:	827	Species:	Rattus norvegicus

Alignment Length:	475	Identity:	104/475 - (21%)
Similarity:	168/475 - (35%)	Gaps:	167/475 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   273 ISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKS-PADSELET-------LNAQDEKIVN 329
            :|..|.......|.:|:    :...|.:.:.||.|.:.. .|:|.|:.       :...|:..||
  Rat     5 VSETRHPLQSEEQEVGI----DPLFSYSNKPRGDSCQNGRGANSNLDCDGTFSSYMREWDDLFVN 65

  Fly   330 N---LPDRQRVERGH------------------PLTETQWLEFQTPDGRISDSARIKELIFRGGV 373
            |   ...||:...|.                  |..::||:            :|||||
  Rat    66 NNYLAAVRQKGINGQLRSSRFRSICWKLFLCVLPQDKSQWI------------SRIKEL------ 112

  Fly   374 VQSLRPEVWKFLLNYYLWSDTHVERIERRK---QKSIEYYNMKAQ-----WLAMTTTQEANFCGY 430
                  ..|     |....:.|:  ...||   |:.:...|..:|     |        ..|...
  Rat   113 ------RSW-----YSNIKEIHI--TNPRKVVGQQDLMINNPLSQDEGSLW--------NKFFQD 156

  Fly   431 RERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPI------ 489
            :|.:..||:||:||...:|||..|:...  :|..:|..|...|..|.|.|||.:|||||
  Rat   157 KELRSMIEQDVRRTFPEMQFFQQENVRK--ILTDVLFCYARENEQLLYKQGMHELLAPIIFTLHC 219

  Fly   490 ---------------------LEIQVNEVDTFWCFVGFMELV---FTNFDID-QAGMKT-----Q 524
                                 |..:..|.|.:..|...||..   |:.|:.| |.|.:|     .
  Rat   220 DHQAFLHASESAQPSEEMKTLLNPEYLEHDAYAMFSQLMETAEPWFSTFEHDGQKGKETLMPPIP 284

  Fly   525 FAQIRRL------IEFANAPLFNYMRSHDSDNMY------------FCFRWLLVWYKRELNSEDV 571
            ||:.:.|      :...|....:.::.||:: :|            :..||:.:.:.||...:|:
  Rat   285 FARPQDLGPTVAIVTKVNQIQDHLLKKHDTE-LYMHLNRLEIPPQIYGLRWVRLLFGREFPLQDL 348

  Fly   572 LKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNE--LSGNIDVQKTLQVAE 634
            |.:|:.|:    ....||    :::|          |.||.:|.::.:  :|.|      .|...
  Rat   349 LVVWDALF----ADGLHL----SLVD----------YVFTAMLLYIRDALISSN------YQTCL 389

  Fly   635 GIYLQLKGSETLPNDIRSII 654
            |:.:..    .|..||.|:|
  Rat   390 GLLMHY----PLIGDIHSLI 405

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	64/290 (22%)
Tbc1d5	XP_008764990.1	TBC	79..381	CDD:214540	78/361 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810