DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and Tbc1d13

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_575106.2	Gene:	Tbc1d13 / 499768	RGDID:	1591937	Length:	400	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	81/385 - (21%)
Similarity:	136/385 - (35%)	Gaps:	128/385 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   363 RIKELIFRGGVVQ-SLRPEVWKFLLNYYLWSDTHVERIER-------RKQKSIEYYNMKAQWLAM 419
            :::||.|.|...: .||...||.||||.        .:||       .||:.: |.....:.:..
  Rat    25 KLRELSFSGIPCEGGLRCLCWKILLNYL--------PLERDSWDSILAKQRGL-YSQFLREMIIQ 80

  Fly   420 TTTQEANFCGYRER-------------------------KCQIEKDVKRTDRSLQFF-------- 451
            ....:||....||.                         ..||:|||:|....:.||
  Rat    81 PGIAKANMGVSREDVTFEDHPLNPNPDSRWNTYFKDNEVLLQIDKDVRRLCPDISFFQRATEYPC 145

  Fly   452 -------------------------------AGEDN-------------------PN-----LTL 461
                                           :|..|                   ||     ..:
  Rat   146 LLILDPQNEFETLRKRVEQTTLKSQTVARNRSGVTNMSSPHKNNAPSALNEYEVLPNGCEAHWEV 210

  Fly   462 LQGILMTYVMYNFDLGYVQGMSDLLAPILEI----------QVNEVDTFWCFVGFMELVFTNF-- 514
            ::.||..|...|..:.|||||::::.|:...          :..|.|||:||...|..:..||
  Rat   211 VERILFIYAKLNPGIAYVQGMNEIVGPLYYTFATDPNSEWKEHAEADTFFCFTNLMAEIRDNFIK 275

  Fly   515 --DIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWEC 577
              |..|.|:..:..::...::..:..|:..::.......:|.||||.:...:|....||:::|:.
  Rat   276 SLDDSQCGITYKMEKVYSTLKEKDVELYLKLQEQSIKPQFFAFRWLTLLLSQEFLLPDVIRIWDS 340

  Fly   578 LWTRLPCPNFHLLFSVAILDQETRVIIDSQY---EFTEILKHVNELSGNIDVQKTLQVAE 634
            |:......:|.||...|:|     ::|..|.   :||..::.:.:...: ||.|.||.|:
  Rat   341 LFADGNRFDFLLLVCCAML-----ILIREQLLKGDFTVNMRLLQDYPIS-DVCKILQKAK 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	69/338 (20%)
Tbc1d13	XP_575106.2	TBC	32..367	CDD:214540	70/348 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810