DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and CG12241

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_650432.1	Gene:	CG12241 / 41834	FlyBaseID:	FBgn0038304	Length:	804	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	95/472 - (20%)
Similarity:	175/472 - (37%)	Gaps:	109/472 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   207 EVYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSPKSRPGV 271
            |.|.......:||:...:|.|:|:           ||..:..:  ::.|.::|        .||.
  Fly    13 EGYVGREEHTRKLQNLGSEDDLGE-----------LPPMMEEL--SVADGLRP--------NPGG 56

  Fly   272 LISGDRQTSPDNYQIIGLSGSTNSACSSNGQSR------GGSAEK--SPADSELETLNAQDEKIV 328
            ..|....:......:..|.|....|...|.|..      |...|:  .|..|..:.|:      :
  Fly    57 PFSALTASMWPQEILAKLGGGAELASGPNDQPEYRFDEFGFRVEEEDGPEQSSNKLLS------I 115

  Fly   329 NNLPDRQR-------VERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLL 386
            ..:.|.|:       :|..|. .|...|.::..|..:..:.:::.:: |.|:..:||.::|..|.
  Fly   116 PFVEDAQQRLQWIAHLEFSHN-KEAAELSWEHVDVMLPRTEKLRNMV-RQGIPHTLRAQMWMRLS 178

  Fly   387 NYYLWSDTHVERIERRKQKSIEYYN--MKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQ 449
            ...           .:||||...|:  :||.......|.:           |||||:.|.   |.
  Fly   179 GAL-----------AKKQKSETSYHDIVKASSNDQLMTSK-----------QIEKDLLRI---LP 218

  Fly   450 FFAGEDNPNLT-------LLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFM 507
            ..|...|||.|       :|:||...:.    |:||.||...::|.:| :.:.|.:.||.....:
  Fly   219 TNACFSNPNGTGIPRLRRILRGIAWLFP----DIGYCQGTGVIVACLL-LFMEEENAFWMMATIV 278

  Fly   508 E---------LVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYK 563
            |         ........||..|.|..|.....::       ..:|.||.:.......|.|..:.
  Fly   279 EDLLPASYYSSTLLGIQADQRVMHTLIANYLSSVD-------ESLRKHDIELSLITLHWFLTLFA 336

  Fly   564 RELNSEDVLKLWECLWTRLPCPNFHL-LFSVAILDQETRVIIDSQYEFTEILKHVNELSGNI-DV 626
            ..::.:.::::|:..:.......|.| |..:.:.:|:.:.:.:|    .:|...::::.|.: ||
  Fly   337 NVVHMKILVRIWDWFFYEGSIVLFQLTLGMLKVKEQDLKHLENS----AQIFNSLSDIPGEVTDV 397

  Fly   627 QKTLQVAEGIYLQLKGS 643
            :...:.|    |::.||
  Fly   398 EVLFRQA----LEVGGS 410

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	54/247 (22%)
CG12241	NP_650432.1	TBC	161..375	CDD:214540	55/251 (22%)
		SH3_SGSM3	540..592	CDD:212747
		RUN	619..773	CDD:280855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456567
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840