DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and tbc1d15

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_989223.1	Gene:	tbc1d15 / 394831	XenbaseID:	XB-GENE-1008350	Length:	666	Species:	Xenopus tropicalis

Alignment Length:	735	Identity:	227/735 - (30%)
Similarity:	341/735 - (46%)	Gaps:	154/735 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 VRYDRCHQVQLGVFNESQLSSVEEDVQNLPQQGTGNILFTHDGVLLKKASAEHIADLNTSGSLSL 69
            |.||     |.|||..|....::|....:|  |...::...:.|::.....|...|  :|..|..
Frog     9 VLYD-----QEGVFIHSSCGKIDEQDTLIP--GILRVIEKDEDVVVDWRPLEETMD--SSNILCA 64

  Fly    70 VEYSRSIAEMPRRRLLLEWQPNDSIMIADDSQD--QGDWALVDRISGRTRTTSECRAFNTRPIEP 132
            .:.|.|:         :||...:..|...|.|:  :.:|.:|:.:|.:.:..:
Frog    65 AKDSSSV---------VEWTTKERGMHLPDHQNSYEAEWDMVNTVSFKKKQFA------------ 108

  Fly   133 SGGATTRSRVMRAQ--------LEDLSSVEVRHRGQ----------------TIRFMRKGANGVH 173
            :||..:   .:.:|        |.||.|::....|.                .:.|.:.|
Frog   109 NGGVQS---PLNSQSKWSFLFSLADLKSIKQNKEGMGWSYFVFCLKDDVVLPALHFHQGG----- 165

  Fly   174 SEFFFQ-HGNADLFVRSMRDQHLI----ENAETSRS-----GGEVYAILTTENQKLKK-----TF 223
            ||...: .|...:|..|.:|..::    :|...|:|     ....|:::    |||||     |.
Frog   166 SELLLECLGKHVMFCESEQDGRILLVSCQNNSLSQSFENLLEESTYSLI----QKLKKDPYTATL 226

  Fly   224 AELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIG 288
            |..                 :|:...|.:......|..||.|:.....|  ||
Frog   227 ASF-----------------SKVTNYLFDTIRGSDPVTQRRPREEMAFL--GD------------ 260

  Fly   289 LSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDE---KIVNNLP--DRQRVERGHPLTETQW 348
                                    |..:|: :|.|:|   :::..:.  .|..|.|..|::..:|
Frog   261 ------------------------AIQDLK-INQQEESGFEVITRIDVGTRPEVHRRDPMSTAEW 300

  Fly   349 LEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMK 413
            ......:|||.:..|||.:||:||:..:||.|||||||.|:.|..|..||...:|:|:.||:.||
Frog   301 EANIDHEGRICNVDRIKNMIFKGGLCHALRKEVWKFLLGYFPWDSTREERAHLQKRKTDEYFRMK 365

  Fly   414 AQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGY 478
            .||.:::..||......|:.:..|||||.||||:.:|:.|.|||.|.||..|||||.||:|||||
Frog   366 LQWKSVSEEQENRNSKLRDYRSLIEKDVNRTDRTNKFYEGPDNPGLNLLHDILMTYCMYDFDLGY 430

  Fly   479 VQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYM 543
            ||||||||:|:|.:..||||.|||||.:|:.:..||:....|||||...:..|:...::...:|:
Frog   431 VQGMSDLLSPVLYVMENEVDAFWCFVSYMDQMHQNFEEQMQGMKTQLVHLSTLLRLLDSGFCSYL 495

  Fly   544 RSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQY 608
            .|.||..:||||||||:.:|||.|.:|.|:|||.:||.|||.|||||...|||:.|.:||::..:
Frog   496 ESQDSGYLYFCFRWLLIRFKREFNFQDTLRLWEVIWTDLPCQNFHLLICCAILESEKQVIMEQHF 560

  Fly   609 EFTEILKHVNELSGNIDVQKTLQVAEGIYLQLKGSETLPNDIRSIIGEPLLPAAAGEEIDGGMVD 673
            .|.|||||:||||..:||...|..||.|.||:...:.||.::..:||..          :.|:..
Frog   561 GFNEILKHINELSMKLDVNDVLSKAEAISLQMMKCKDLPLNVCDVIGIK----------NNGVAG 615

  Fly   674 EEPTYSDDGFDELVKELTPE 693
            .....|::...:..|:.:|:
Frog   616 PNEATSEENLAKKHKKSSPQ 635

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	31/180 (17%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	119/228 (52%)
tbc1d15	NP_989223.1	DUF3548	8..205	CDD:371881	45/233 (19%)
tbc1d15	NP_989223.1	TBC	321..556	CDD:214540	121/234 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H11249
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	1	1.000	-	-		FOG0002107
OrthoInspector	1	1.000	-	-		otm48739
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1395
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.010