DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d2

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006538109.1	Gene:	Tbc1d2 / 381605	MGIID:	2652885	Length:	923	Species:	Mus musculus

Alignment Length:	679	Identity:	135/679 - (19%)
Similarity:	254/679 - (37%)	Gaps:	191/679 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 ESQLSSVEEDVQNLPQQGTGN---ILFTHDGVLL----KKASAEHIADLNTSGSLSLVEYS-RSI 76
            :.:::::|:.|..|.::....   ::..|..:..    |:||:.::|.......|.||.:. |.|
Mouse   309 QEKVAALEQQVLMLTKELKSQKELVIILHKALEAAQQEKRASSAYLAATEDRDRLELVRHKVRQI 373

  Fly    77 AEMPRRRLLLEWQPNDSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTRSR 141
            ||:.:|...||                         .||.|...|              |..|.:
Mouse   374 AELNQRVEALE-------------------------QGRERLAHE--------------AGLREQ 399

  Fly   142 VMRAQLEDLS-SVEVRHRGQTI---------RFMRKGANGVHSEFFFQHGNADLFVRSMRDQHLI 196
            .::|..:.:. .::..|..|.:         ..:.:.|:..:.:|..|         ..|.:||.
Mouse   400 QVQALQQHVQLLMDKNHAKQQVICKLTQKLTEDLAQPADATNGDFLSQ---------QERMEHLK 455

  Fly   197 ENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNK--------LAGI---- 249
            ::.|..|:...   .|.:|..::.|.:.:  :.:.:.:.|.:.::|..:        |||:
Mouse   456 DDMEAYRTQNR---FLNSEIHQVTKIWRK--VAEKEKALLTKCAYLQARNCQVESKYLAGLRRLQ 515

  Fly   250 ------LGNIPDYVQPPFQRSPKSRPGVLISGDRQTSP----DNYQIIGLSGSTNSACSSNGQSR 304
                  .|:.|:.:|...|.:.:...|...|..  .||    |:|..:
Mouse   516 EAAGAEAGDFPELLQQLIQEALQWEAGEADSVG--LSPVSEYDDYGFL----------------- 561

  Fly   305 GGSAEKSPADSELETLN--AQDEKI---VNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARI 364
                  :..|.|:|.|.  |:.:.:   .::|...:.|||  ||.: :|....    .::.||.:
Mouse   562 ------TVPDYEMEDLKLLAKIQALEVRSHHLLAHEAVER--PLRD-RWATLT----ELTPSAEL 613

  Fly   365 KELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCG 429
            |:|: |.||.:..||.||::|          |.|..|..|....|..:.|
Mouse   614 KQLL-RAGVPREHRPRVWRWL----------VHRRVRHLQAPGCYQELLA--------------- 652

  Fly   430 YRERKC------QIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAP 488
             |.|.|      |||.|:.||..:.:.|....:.....|:.:|:.:...|..:||.||::.|.|.
Mouse   653 -RGRACEHPAARQIELDLNRTFPTNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAI 716

  Fly   489 ILEIQVNEVDTFWCFVGFMELV---------FTNFDIDQAGMKTQFAQ-IRRLIEFANAPLFNYM 543
            .|.:..:|...|||.|..:|.:         .|...:||..::...:: :.||..        ::
Mouse   717 ALLVLEDEESAFWCLVAIVETILPAEYYSKTLTASQVDQRVLQDLLSEKLPRLTA--------HL 773

  Fly   544 RSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECL---WTRLPCPNFHLLFSVAILDQETRVIID 605
            ..|..|.....|.|.||.:...|.|:.:|::|:..   .|::.     ..:::||.......|:.
Mouse   774 GQHRVDLSLITFNWFLVVFADSLISDILLRVWDAFLYEGTKVV-----FRYALAIFKYNEEAILQ 833

  Fly   606 SQYEFTEILKHVNELSGNI-DVQKTLQVA 633
            .| :..||.:::...:..| |.:|.:.:|
Mouse   834 LQ-DSLEIYQYLRFFTKTICDSRKLMSIA 861

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	27/171 (16%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	58/247 (23%)
Tbc1d2	XP_006538109.1	PH_TBC1D2A	45..146	CDD:269966
		PRK14951	<192..404	CDD:237865	24/133 (18%)
		COG4913	<300..>565	CDD:227250	53/333 (16%)
		TBC	620..832	CDD:214540	57/250 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900