DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and Tbc1d10a

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001015022.1	Gene:	Tbc1d10a / 360968	RGDID:	1311641	Length:	505	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	97/461 - (21%)
Similarity:	163/461 - (35%)	Gaps:	120/461 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   263 RSPKSRPGVLISGDRQT---SPDNYQIIGLSGSTNSACSSNG---------------QSRGGSAE 309
            |:|.|  |..:||.|::   .||......|| |..|...:||               |...|:.|
  Rat    11 RAPAS--GGSLSGTRESLAQGPDAATADELS-SLGSDSEANGFAERRIDKFGFIVGSQGAEGALE 72

  Fly   310 KSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLE-FQTPDGRISDSARIKELIFRGGV 373
            :.|    ||.|             |||        |::||: ....|..::...:...|..:.|:
  Rat    73 EVP----LEVL-------------RQR--------ESKWLDMLNNWDKWMAKKHKKIRLRCQKGI 112

  Fly   374 VQSLRPEVWKFLLNYYLWSDTHVERIERRKQK--SIEYYNMKAQWLAMTTTQEANFCGYRERKCQ 436
            ..|||...|::|      |...| ::::...|  .::......:||.:
  Rat   113 PPSLRGRAWQYL------SGGKV-KLQQNPGKFDELDMSPGDPKWLDV----------------- 153

  Fly   437 IEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFW 501
            ||:|:.|.....:.|..........|..:|..|.:|..:.||.|..:. :|.:|.:.:.....||
  Rat   154 IERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAP-IAAVLLMHMPAEQAFW 217

  Fly   502 CFVGFMELVFTNF-----DIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVW 561
            |.|...|.....:     :..|...:..|:.::::...|:    .::.....|.:.:...|.:..
  Rat   218 CLVQVCEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAH----KHLSRQKIDPLLYMTEWFMCA 278

  Fly   562 YKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAIL-------DQETRVIIDSQYEFTEILKHVNE 619
            :.|.|....||::|:..:    |....::|.|.::       ..|.......|||..|.|:   .
  Rat   279 FARTLPWSSVLRVWDMFF----CEGVKIIFRVGLVLLKHALGSPEKLRACQGQYETIEQLR---S 336

  Fly   620 LSGNIDVQKTLQVAEGIYLQLKGSETLPNDIRSIIGEPLLPAAAGEEIDG--------------G 670
            ||..| :|:...|.|.|        .||...|.|..|.|:.....:|..|              .
  Rat   337 LSPKI-MQEAFLVQEVI--------ELPVTERQIEREHLIQLRRWQETRGELECRSPPRMHGAKA 392

  Fly   671 MVDEEP 676
            ::|.||
  Rat   393 ILDAEP 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	43/242 (18%)
Tbc1d10a	NP_001015022.1	TBC	110..313	CDD:214540	43/235 (18%)
Tbc1d10a	NP_001015022.1	VCX_VCY	404..>501	CDD:291884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810