DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and TBC1D26

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001375394.1	Gene:	TBC1D26 / 353149	HGNCID:	28745	Length:	468	Species:	Homo sapiens

Alignment Length:	305	Identity:	65/305 - (21%)
Similarity:	116/305 - (38%)	Gaps:	66/305 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   328 VNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWS 392
            |:.|..:||  |.......:|.:......:...:.::.:.::: .:..::|...|..||:
Human    60 VSALEVKQR--RKESKRTNKWQKMLADWTKYRSTKKLSQRVYK-VIPLAVRGRAWSLLLD----- 116

  Fly   393 DTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERK---CQIEKDVKRTDRSLQFFAGE 454
               ::||  :.|...:|..||.:             |.|..:   | |:.||..|.:....|...
Human   117 ---IDRI--KSQNPGKYKVMKEK-------------GKRSSRIIHC-IQLDVSHTLQKHMMFIQR 162

  Fly   455 DNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQA 519
            .......|..||:.|..||.::||.:.:|.:.| ||.:.:.|.|.||.....:.:.::
Human   163 FGVKQQELCDILVAYSAYNPEVGYHRDLSRITA-ILLLCLPEEDAFWALTQLLAVFYS------- 219

  Fly   520 GMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPC 584
               ...|.:.||:            ||....::..|..::    |.|..|.:......|...|.|
Human   220 ---PNTAWLERLL------------SHQEQVLHKSFPKIM----RHLGKEGLCIEGSMLTRLLRC 265

  Fly   585 ----PNFHL---LFSVAILDQETRVIIDSQYEFTEI-LKHVNELS 621
                .:|.|   |:.|.|| :..||:....:...:| .||:.:||
Human   266 FLDGKSFGLTLRLWDVFIL-EGARVLTAMVHASFKIHRKHLMKLS 309

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	52/238 (22%)
TBC1D26	NP_001375394.1	TBC	98..306	CDD:214540	57/260 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900