DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and CG1695

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_728346.2	Gene:	CG1695 / 33046	FlyBaseID:	FBgn0031116	Length:	1192	Species:	Drosophila melanogaster

Alignment Length:	983	Identity:	189/983 - (19%)
Similarity:	305/983 - (31%)	Gaps:	439/983 - (44%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 GVFNESQLSSVEED-VQNLPQQGTGNILFTHDGVL-LKKASAEHIADLNTSGSLSLVEYSRSIAE 78
            |.|.....:||.:| |::|.|.....:|:..:.|| |.|..:|.:     .|.|||.:..:|
  Fly   286 GSFKACSPASVAKDYVESLHQNSRTTLLYGKNNVLVLPKDVSEPM-----PGYLSLHQSIQS--- 342

  Fly    79 MPRRRLLLEWQPNDSIMIADDSQDQGD----WAL-----VDRI------------SGRTRTTSEC 122
                 |.::|.|| .:|...:..|.||    |:.     ||.|            :|.|......
  Fly   343 -----LTIKWTPN-QLMNGYNDGDGGDKSFYWSYALNINVDEIVYVHCHQNRGGDTGGTIILVGQ 401

  Fly   123 RAFNTRPIE-PSGGATTRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLF 186
            ......||. |.||.      ::|.|..|.:..:.| ||           :....:.|.|...||
  Fly   402 DGVQRPPIHFPEGGH------LQAFLSCLETGLLPH-GQ-----------LDPPLWSQRGIGKLF 448

  Fly   187 --VRSMRDQHLIENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGI 249
              .:|:| :|::.:  ...:||.|     |:...:...|..:       |:...|.:|
  Fly   449 PWPKSVR-RHILPS--VMEAGGSV-----TDETPIDYVFRVV-------SKCQHEEFL------- 491

  Fly   250 LGNIPDYVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPAD 314
                            .|.| :|..|  ::||....:...|.:.:|.|||...|...|:.::|..
  Fly   492 ----------------ASHP-ILELG--RSSPRRKHLGSCSTTGSSDCSSKSLSIDQSSCETPLI 537

  Fly   315 S-------------------------------ELETLNAQDEKIVNN--LPDRQRVERGHPLTET 346
            .                               .|.|:......:||.  :||....|.|  ||..
  Fly   538 QASQSTSIELVCSTMRRQIISRAFYGWLAYCRHLSTVRTHLSGLVNGRIMPDLAADEEG--LTRG 600

  Fly   347 QWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYY- 410
            :||... .||.::....:..|::.|||...||.|||.:||.:|.:..|..||  :::.::.::|
  Fly   601 KWLAMH-EDGVVTGDLELYRLVYFGGVEPELRKEVWPYLLGHYDFGSTPEER--KKQDETCKHYY 662

  Fly   411 -NMKAQWLAMTTT---------------------------------------------------- 422
             ...::|||:...
  Fly   663 ETTMSEWLAVEAIVRQREKEKTALAVAKLSAEQARLAANATSSSNPHQKLANGSQQLQLEHGNGE 727

  Fly   423 -------------------------------------QEA------------------------- 425
                                                 |||
  Fly   728 EDQENLVLDEGENDVFDDNDFSDISDPGDLFDEPELGQEAEEQEQSNLEEEVFEKQEDEEDQEDH 792

  Fly   426 ----------------------------------------------------------------- 425

  Fly   793 DQREMPRLSEKLVLEFQNIDNMEPLRLQENCFADSETENDLGLGLDSSGNILMLSIKSSPSTSSY 857

  Fly   426 -----NFCGYRERKCQ------------------------------------------------- 436
                 .|....|.|.:
  Fly   858 ETVGNEFLDMAEAKLEEEEPPGQLSKFHSADDVRLDNQDEEESSQPATAVIITEAASLDALDDDP 922

  Fly   437 ------------------------------------------------------------IEKDV 441
                                                                        |||||
  Fly   923 TEEFTSRKTSLMSPLNEDITVVASLDALQEPKSACVSPASSNGGVYSVELLEQFGLNLHRIEKDV 987

  Fly   442 KRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGF 506
            :|.||:..:||   |.||..|:.::.|||..:.|:||:|||.||:||:|.|..:|..::.||...
  Fly   988 QRCDRNYWYFA---NENLDKLRNVISTYVWEHLDVGYMQGMCDLVAPLLVIFDDESLSYSCFCKL 1049

  Fly   507 MELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSH-DSDNMYFCFRWLLVWYKRELNSED 570
            ||.:..||....| |...||.:|.||:..::.:::.|.|: |..:.|||:||.|:.:||||..:|
  Fly  1050 MERMIENFPSGGA-MDMHFANMRSLIQILDSEMYDLMDSNGDYTHFYFCYRWFLLDFKRELVYDD 1113

  Fly   571 VLKLWECLWT--RLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVA 633
            |...||.:|.  .:...:|.|..::|:|:....:|:.:..:||:::|..||::...:.|..||::
  Fly  1114 VFATWEVIWAAKHIASGHFVLFLALALLETYRDIILSNSMDFTDVIKFFNEMAERHNAQSILQLS 1178

  Fly   634 EGIYLQLK 641
            ..:.|||:
  Fly  1179 RSLVLQLQ 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	41/178 (23%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	89/526 (17%)
CG1695	NP_728346.2	RUN	63..237	CDD:280855
		PH_RUTBC	310..485	CDD:275431	49/221 (22%)
		SRP68-RBD	<648..>713	CDD:304552	6/66 (9%)
		TBC	947..1124	CDD:214540	61/180 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456563
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR22957
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840