DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d2

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006238118.1	Gene:	Tbc1d2 / 313234	RGDID:	1306860	Length:	924	Species:	Rattus norvegicus

Alignment Length:	704	Identity:	141/704 - (20%)
Similarity:	256/704 - (36%)	Gaps:	199/704 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 KKASAEHIADLNTSGSLSLVEYS-RSIAEMPRRRLLLEWQPNDSIMIADDSQDQGDWALVDRI-- 112
            |:||:.::|.......|.||.:. |.|||:.:|...|| |..:.::.....::|...||...:
  Rat   345 KRASSAYLAATEDRDRLELVRHKVRQIAELNQRVEALE-QDRERLVHEAGLREQQVQALQQHVQL 408

  Fly   113 ---SGRTRTTSECRAFNTRPIEPSGGATTRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHS 174
               ..:.:....|                  ::.:...|||:..:             .|:..:.
  Rat   409 LMDKNQAKQQVIC------------------KLSQKLTEDLAQPQ-------------PADATNG 442

  Fly   175 EFFFQHGNADLFVRSMRDQHLIENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRE 239
            :|..|         ..|.:||.::.|..|:...   .|.:|..::.|.:.:  :.:.:.:.|.:.
  Rat   443 DFLSQ---------QERLEHLKDDMEAYRTQNR---FLNSEIHQVTKIWRK--VAEKEKALLTKC 493

  Fly   240 SWLPNK--------LAGIL----------GNIPDYVQPPFQRSPKSRPGVLISGDRQTSP----D 282
            ::|..:        |||:.          |:.|:.:|...|.:.:...|. .|.....||    |
  Rat   494 AYLQARNCQVESKYLAGLRRLQEAAGAEPGDFPELLQQLVQEALQWEAGE-ASDSVGLSPVSEYD 557

  Fly   283 NYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVE-RGHPLTET 346
            :|..:                       :..|.|:|     |.|::..:   |.:| |.|.|...
  Rat   558 DYGFL-----------------------TVPDYEVE-----DLKLLAKI---QALEVRSHHLLAL 591

  Fly   347 QWLEFQTPD-----GRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQ-- 404
            :.:|....|     ..:..||.:|:|: |.||.:..||.||::|             :.||.|
  Rat   592 EAVERPLRDRWATLTELMPSAELKQLL-RAGVPREHRPRVWRWL-------------VHRRVQHL 642

  Fly   405 -KSIEYYNMKAQWLAMTTTQEANFCGYRERKC------QIEKDVKRTDRSLQFFAGEDNPNLTLL 462
             .|..|..:.|                |.|.|      |||.|:.||..:.:.|....:.....|
  Rat   643 HSSGCYQELLA----------------RGRACEHPAARQIELDLNRTFPTNKHFTCPTSSFPDKL 691

  Fly   463 QGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELV---------FTNFDIDQ 518
            :.:|:.:...|..:||.||::.|.|..|.:..:|...|||.|..:|.:         .|...:||
  Rat   692 RRVLLAFSWQNPTIGYCQGLNRLAAIALLVLEDEESAFWCLVAIVETILPAEYYSKTLTASQVDQ 756

  Fly   519 AGMKTQFAQ-IRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECL---W 579
            ..::...:: :.||..        ::.....|.....|.|.||.:...|.|:.:|::|:..   .
  Rat   757 RVLQDLLSEKLPRLTA--------HLGQRHVDLSLITFNWFLVIFADSLISDILLRVWDAFLYEG 813

  Fly   580 TRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNI-DVQKTLQVA---------- 633
            |::.     ..:::||.......|:..| :..||.:::...:..| |.:|...:|
  Rat   814 TKVV-----FRYALAIFKYNEEAILRLQ-DSLEIYQYLRFFTKTICDSRKLTSIAFNDMNPFPMK 872

  Fly   634 EGIYLQLKGSETLPNDIRSIIGEPLLP-------AAAGEEIDGGMVDEEPTYSD 680
            :...|:....|.|..::|.:   .||.       |:.|..:..|.|.|:....|
  Rat   873 QLRQLRAAHRERLEAELREL---ELLKAEYLERRASRGRAVPEGCVSEDEGEGD 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	25/145 (17%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	57/250 (23%)
Tbc1d2	XP_006238118.1	PH_TBC1D2A	44..145	CDD:269966
		PH	44..137	CDD:278594
		TBC	621..833	CDD:214540	56/253 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900