Protein Alignment Tbc1d15-17 and Rabgap1

DIOPT Version :9

• Sequence 1: NP_001259806.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001101311.1
• Gene: Rabgap1 / 311911
• RGDID: 1304691
• Length: 1065
• Species: Rattus norvegicus
• Alignment Length: 602
• Identity: 129/602 - (21%)
• Similarity: 224/602 - (37%)
• Gaps: 125/602 - (20%)

  Fly   192 DQHLIENAETSRSG-GEVYAILTTENQK-----------------LKKTFAELDIGQIKASQLPR 238
            |.||::.....:|. |:.|.|..:.|.|                 ...|..:|.|.::   |.|.
  Rat   357 DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEV---QEPV 418

  Fly   239 ESWLPNKLAGILGNIPDYVQPPF-QRSPKSRPGVLISGDRQTSPDN-----YQIIGLSG------ 291
            ...|..|:.....|  :.:..|| :||......:.:...:|....|     |:::.|..
  Rat   419 RFLLETKVRVCSPN--ERLFWPFSKRSTTENFFLKLKQIKQKEKKNNADTLYEVVCLESESERER 481

  Fly   292 -STNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPD 355
             .|.::.|......|..:...|:..|.:.....||.:::...|..: |....:.|| |.|..: .
  Rat   482 RKTTASPSVRLPQSGSQSSMIPSPPEDDEEEDNDEPLLSGFGDVSK-ECAEKILET-WGELLS-K 543

  Fly   356 GRISDSARIKEL--IFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLA 418
            ..::.:.|.|:|  :.|.||.::||.|||:.|...:  ::.|:          :|.|.
  Rat   544 WHLNLNVRPKQLSSLVRSGVPEALRGEVWQLLAGCH--NNDHL----------VEKYR------- 589

  Fly   419 MTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMS 483
            :..|:|:      .:...|.:|:.||..:..:|..........|..|...|.:|:.::||.||.|
  Rat   590 ILITKES------PQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQS 648

  Fly   484 DLLAPILEIQVNEVDTFWCFV------GFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNY 542
             .||.:|.:.:.|...|...|      |..||...||:    .:..:|.|:.||::.....|:|:
  Rat   649 -FLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFE----DLHCKFYQLERLMQEYIPDLYNH 708

  Fly   543 MRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQET------- 600
            ......:...:..:|.|..:..:.....|..:.:.|.    |....::|:||:...:|
  Rat   709 FLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLL----CEGISVIFNVALGLLKTSKDDLLL 769

  Fly   601 ----------RVIIDSQYEFTEILKHVNELSGNIDV-QKTLQVAEGIYLQLKGSETLPND-IRSI 653
                      ||.:..:|...|..|.:.||:.|..: ||.|:..|..|..::..:....| |...
  Rat   770 TDFEGALKFFRVQLPKRYRSEENAKRLMELACNTKISQKKLKKFEKEYHTMREQQAQQEDPIERF 834

  Fly   654 IGEPLLPAAAG---EEIDGGMVDEEPT----------YSDDGFDELVKEL---------TPEEKV 696
            ..|......|.   |:.:..:..|..|          .:::..|.|.|||         ..:||.
  Rat   835 ERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEDEKR 899

  Fly   697 R---QQALLEEACERSL 710
            |   :.|.|:|.|.|.|
  Rat   900 RLEEESAQLKEMCRREL 916

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
		TBC	369..598	CDD:214540	53/234 (23%)
Rabgap1	NP_001101311.1	PTB_Rab6GAP	141..269	CDD:269922
		DUF3694	303..433	CDD:403614	17/80 (21%)
		TBC	559..768	CDD:214540	54/242 (22%)
		ERM	790..1016	CDD:395622	31/127 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810