DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d9

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006255308.1	Gene:	Tbc1d9 / 304645	RGDID:	1308221	Length:	1262	Species:	Rattus norvegicus

Alignment Length:	517	Identity:	99/517 - (19%)
Similarity:	194/517 - (37%)	Gaps:	132/517 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   244 NKLAGILGNIPD---YVQ--PPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQS 303
            |::..:..|:.|   .||  ..|.:...||.....||...:|.|...      |..|:..|:...
  Rat   376 NRMTFLFANLKDRDFLVQRISDFLQQTTSRIYSEFSGSCNSSDDEVY------SRPSSLVSSSPQ 434

  Fly   304 RGGSAEKSPADSELE-TLNAQDEKIVNNLPD----------RQRVERGHPLTETQWLEFQTPDGR 357
            |..|   |.||.|.. .||.      |::|.          |:..|..:|....::|:.|.....
  Rat   435 RSTS---SDADGERPFNLNG------NSVPTATQTLMTMYRRRSPEEFNPKLAKEFLKEQAWKIH 490

  Fly   358 ISD---------SARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMK 413
            .::         :.:.:||:.: |:.:.:|.|:|..|........||....|...:||:..||:.
  Rat   491 FAEYGQGICMYRTEKTRELVLK-GIPERMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLA 554

  Fly   414 AQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGY 478
            .:                    :||:|:.|:......|..|  ..:..|:.:|..|...|.::||
  Rat   555 TE--------------------EIERDLHRSLPEHPAFQNE--MGIAALRRVLTAYAFRNPNIGY 597

  Fly   479 VQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFD--------IDQAGMKTQFAQIRRLIEFA 535
            .|.| :::..:|.:...|.:.||..|...|.:..::.        :||.    .|.::.|
  Rat   598 CQAM-NIVTSVLLLYAKEEEAFWLLVALCERMLPDYYNTRVVGALVDQG----VFEELAR----- 652

  Fly   536 NAPLFNYMRSHDSDNMYFCFR-----------WLLVWYKRELNSEDVLKLWECLWTRLPCPNFHL 589
                 :|:     ..:|.|.:           |.|..:...:..|..:.:.:|.:..    ...:
  Rat   653 -----DYV-----PQLYDCMQDLGVISTISLSWFLTLFLSVMPFESAVVVVDCFFYE----GIKV 703

  Fly   590 LFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQ--LKGSETLP--NDI 650
            :|.:|:      .::|:         :|::|.|..|..:.:.|. |.||.  .....|||  ..:
  Rat   704 IFQLAL------AVLDA---------NVDKLLGCKDDGEAMTVL-GRYLDSVTNKDSTLPPIPHL 752

  Fly   651 RSIIGEPLLPAAAGE--EIDGGMVDEEPTYSDDGFDELVKELTPEEKVRQQALLEEACERSL 710
            .|::.:.:.|..|.:  .:.|...::..|...|    |::::..:::::....||:..:|::
  Rat   753 HSLLSDDVGPYPAVDIFRLIGTSYEKFGTIRAD----LIEQMRFKQRLKVIQTLEDTTKRNV 810

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	45/247 (18%)
Tbc1d9	XP_006255308.1	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	5/22 (23%)
		TBC	510..720	CDD:214540	47/271 (17%)
		EFh	<891..921	CDD:298682
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900