DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and Sgsm2

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006246802.1	Gene:	Sgsm2 / 303304	RGDID:	1306957	Length:	1050	Species:	Rattus norvegicus

Alignment Length:	884	Identity:	185/884 - (20%)
Similarity:	300/884 - (33%)	Gaps:	329/884 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 LGVFNESQLSSVEED---------VQNLPQQGTGNILFTHDGVLLK-KASAEHIADLNTSGSLSL 69
            ||:.......|..||         |::|.|.....:|:..:.||:: |...|.:     .|.|||
  Rat   223 LGIRKRHSSGSASEDRLAACAREYVESLHQNSRTRLLYGKNNVLVQPKEDMEAV-----PGYLSL 282

  Fly    70 VEYSRSIAEMPRRRLLLEWQPNDSI--MIADDSQDQG---DWALV------------DRISGRTR 117
            .:.:.:        |.|:|.||..:  .:.|...::.   |:|||            .:.||.|.
  Rat   283 HQSAEN--------LTLKWTPNQLMNGTLGDSELEKSVYWDYALVVPFSQIVCVHCHQQKSGGTL 339

  Fly   118 TTSECRAFNTRPIE-PSGGATTRSRVMRAQLEDLSSVE--VRHRGQTIRFMRKGANGVHSEFFFQ 179
            ...........|:. |.||..         |..||.:|  :..|||           :....:.|
  Rat   340 VLVSQDGIQRPPLHFPQGGHL---------LSFLSCLENGLLPRGQ-----------LEPPLWTQ 384

  Fly   180 HGNADLFVRSMRDQHLI-----ENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRE 239
            .|...:|.: :|.:..|     |.....|:...|:.|:...::....|.....:...:|:.:..:
  Rat   385 QGKGKVFPK-LRKRSSIRSIDAEELGVGRATDYVFRIIYPGHRHEHITINYHHLAASRAASVDDD 448

  Fly   240 SWLPNKLAGILGNIPDYVQPPFQRSPKSRPGVLISGDRQTSP----DNYQIIGLSG--------- 291
            ....:||..:|.                    :|.....|:|    |...:|.:.|
  Rat   449 EEEEDKLHAMLS--------------------MICSRNLTAPNPMKDAGDMIEMQGFGPSLTAWH 493

  Fly   292 -----STNSACSSNGQSRGGSAEKSPAD-------------------------------SELETL 320
                 |..|:|.|...|....|..|...                               ..|.|:
  Rat   494 LEPLCSQGSSCLSCPSSSSPYAPPSHCSCTPDRLPLRLLCESMKRQIVSRAFYGWLAYCRHLSTV 558

  Fly   321 NAQDEKIV-NNL--PDRQRVERGHPLTETQWLEFQTPDGRISDSARIKEL-----IFRGGVVQSL 377
            ......:| :|:  |||.....| .||:..|.::|      .|....|||     ::.|||...:
  Rat   559 RTHLSALVHHNIIPPDRPPGASG-GLTKDVWSKYQ------KDKKNYKELELLRQVYYGGVEHEI 616

  Fly   378 RPEVWKFLLNYYL-------------------------WS------------------------- 392
            |.:||.|||.:|.                         |.
  Rat   617 RKDVWPFLLGHYKFGMSKKEMEQVDAAVAARYQQVLAEWKACEVVVRQREREAHPATLTKFSSGS 681

  Fly   393 --DTHVERIERR--------------------------------------------KQKSIEY-- 409
              |:||:|:..|                                            :|:|:|:
  Rat   682 SIDSHVQRLVHRDSTISNDVFISVDDLEPPGPQDPEDSKPKQEREPGAGTPGTAAAEQQSVEFES 746

  Fly   410 ----------YNMKAQWLAMTTTQEANFCGYRE-------------------------------- 432
                      |::.:.  ..::..||...|:.|
  Rat   747 PDSGLPSSRNYSVASG--IQSSLDEAQSVGFEEDGAGEEGSEEPATAAHTFLGPHDPDQEKLAPA 809

  Fly   433 ----------RKC-----------------QIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYV 470
                      ..|                 :|:|||:|.||:..:|.   .|||..|:.|:.:||
  Rat   810 SELEGGEELTAVCAATYTIELLDTVALNLHRIDKDVQRCDRNYWYFT---TPNLERLRDIMCSYV 871

  Fly   471 MYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFA 535
            ..:.|:||||||.|||||:|.|..|:...:.||...|:.:..||. :...|.|.||.:|.||:..
  Rat   872 WEHLDMGYVQGMCDLLAPLLVILDNDQLAYSCFSHLMKRMSQNFP-NGGAMDTHFANMRSLIQIL 935

  Fly   536 NAPLFNYMRSH-DSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWT--RLPCPNFHLLFSVAILD 597
            ::.||..|..: |..:.|||:||.|:.:||||..|:|..:||.:|.  .:...:|.|..::|:::
  Rat   936 DSELFELMHQNGDYTHFYFCYRWFLLDFKRELLYEEVFAVWEVIWAARHISSEHFVLFIALALVE 1000

  Fly   598 QETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGI 636
            ....:|.|:..:||:|:|..||.:...|.|:.|::|..:
  Rat  1001 AYREIIRDNNMDFTDIIKFFNERAERHDAQEILRIARDL 1039

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	36/174 (21%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	89/398 (22%)
Sgsm2	XP_006246802.1	RUN	42..189	CDD:280855
		PH_RUTBC	256..424	CDD:275431	42/201 (21%)
		TBC	<838..1006	CDD:214540	64/171 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810