DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Sgsm1

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_017453793.1	Gene:	Sgsm1 / 288743	RGDID:	1308178	Length:	1096	Species:	Rattus norvegicus

Alignment Length:	985	Identity:	184/985 - (18%)
Similarity:	298/985 - (30%)	Gaps:	447/985 - (45%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 DESVRYDRCHQVQL----------------------GVFNESQLSSVEEDVQNLPQQGTGNILFT 44
            ||.|:..|.|...|                      |..::....|..:.|::|.|.....:|:.
  Rat   198 DELVQRHRIHSSHLRQDSPTKRPALCVRWIQKRHSSGSMDDRPSISARDYVESLHQNSRATLLYG 262

  Fly    45 HDGVLLKKASAEHIADLN-TSGSLSLVEYSRSIAEMPRRRLLLEWQPNDSI--MIADDSQDQG-- 104
            .:.||::...     |:. ..|.|||    ...|::    :.|:|.||..:  .:.|...::.
  Rat   263 KNNVLVQPRD-----DMEAVPGYLSL----HQTADV----MTLKWTPNQLMNGSVGDLDYEKSVY 314

  Fly   105 -DWALVDRI-------------SGRTRTTSECRAFNTRPIE-PSGGATTRSRVMRAQLEDLSSVE 154
             |:|:..|:             ||.|............|.. |.||..         |:.||.:|
  Rat   315 WDYAVTIRLEEIVYLHCHQQVDSGGTVVLVSQDGIQRPPFRFPKGGHL---------LQFLSCLE 370

  Fly   155 VRHRGQTIRFMRKGANGV--HSE----FFFQHGNADLF--VRSMRDQHLIENAETSRSGGE---- 207
                           ||:  |.:    .:.|.|...:|  :|....|...|:..:.:...|
  Rat   371 ---------------NGLLPHGQLDPPLWSQRGKGKVFPKLRKRSPQGSSESTSSDKEDDEATDY 420

  Fly   208 VYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGI-LGNIPDYVQPPFQRSPKSRPGV 271
            |:.|:....|                     ..::|..|..: :.|:|...||    ||:.
  Rat   421 VFRIIYPGTQ---------------------SEFVPQDLMDVSMNNLPSLWQP----SPRK---- 456

  Fly   272 LISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSA-----EKSP----ADS------------ 315
                                |:.|:||.:|.:.|.|.     |::|    .|:
  Rat   457 --------------------SSCSSCSQSGSADGSSTNGCNHERAPLKLLCDNMKYQILSRAFYG 501

  Fly   316 ------ELETLNAQDEKIVNNL---PDRQRVERGHPLTETQWLEFQTPDGRISDSARIKE----- 366
                  .|.|:......:||::   ||.. .:.|..||.:.|.::      |.||....|
  Rat   502 WLAYCRHLSTVRTHLSALVNHMIVSPDLP-CDAGQGLTASIWEQY------IQDSTTYPEQELLR 559

  Fly   367 LIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWL-------------- 417
            ||:.|||...:|..||.|||.:|.:..|.:||.|..:|....|....::||
  Rat   560 LIYYGGVQPEIRRAVWPFLLGHYQFGMTEMERKEVDEQIHACYAQTMSEWLGCEAIVRQRERESH 624

  Fly   418 ------------------------AMTTTQEANFC------------------------------ 428
                                    :..:.:.:..|
  Rat   625 AAALAKCSSGASLDSHLHRMLHRDSTISNESSQSCSSGRQNLRLQSDSSSSTQVFESVDEVEQTE 689

  Fly   429 --GYRERK-------------C------------------------------------------- 435
              |..|.|             |
  Rat   690 AEGRSEEKHPKIPNGNPANGTCSPDSGHPSSHNFSSGLSEHSEPSLSTEDSVLDVQRSLPAVFRP 754

  Fly   436 ----------------------------------------------------------------- 435

  Rat   755 GDSSVEDGQSSEATTSRDEAPREELAVQDSLESDLLANESLEEFMSIPGSLDVALPEKDGAMMDG 819

  Fly   436 ----------------------------------------------------------------- 435

  Rat   820 WPGEADKHGRADSEDNLSEEPEMESLFPALASLAVTSSANNETSPVSSSGVTYSPELLDLYTVNL 884

  Fly   436 -QIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDT 499
             :|||||:|.|||..:|..   .||..|:.|:.:|:..:.::||||||.|||||:|.|..:|...
  Rat   885 HRIEKDVQRCDRSYWYFTA---ANLEKLRNIMCSYIWQHIEIGYVQGMCDLLAPLLVILDDEALA 946

  Fly   500 FWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSH-DSDNMYFCFRWLLVWYK 563
            |.||...|:.:..||....| |.|.||.:|.||:..::.||..|..: |..:.|||:||.|:.:|
  Rat   947 FSCFTELMKRMNQNFPHGGA-MDTHFANMRSLIQILDSELFELMHQNGDYTHFYFCYRWFLLDFK 1010

  Fly   564 RELNSEDVLKLWECLWTRLPCPNFH--LLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDV 626
            |||..:||..:||.:|......:.|  |..::|:::....:|:::..:||:|:|..||::...:.
  Rat  1011 RELVYDDVFSVWETIWAAKHVSSAHYVLFIALALVEVYRDIILENNMDFTDIIKFFNEMAERHNA 1075

  Fly   627 QKTLQVAEGI 636
            ::.||:|..:
  Rat  1076 KQILQLARDL 1085

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	35/181 (19%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	88/488 (18%)
Sgsm1	XP_017453793.1	RUN	44..186	CDD:397055
		PH_RUTBC	257..428	CDD:275431	40/207 (19%)
		TBC	<884..1053	CDD:214540	65/172 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810