Protein Alignment Tbc1d15-17 and gyp7

DIOPT Version :9

• Sequence 1: NP_001259806.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_592900.1
• Gene: gyp7 / 2543609
• PomBaseID: SPAC630.05
• Length: 743
• Species: Schizosaccharomyces pombe
• Alignment Length: 682
• Identity: 181/682 - (26%)
• Similarity: 293/682 - (42%)
• Gaps: 134/682 - (19%)

  Fly    25 SVEEDVQNLPQQGTGNILFTHDGVLL------KKASAEHIADLNTSGS---------LSLVEYSR 74
            ::.:..::||.      ||.||...:      |:.:.:.....:.||:         :.|.:|:
pombe   144 NLRDSGESLPP------LFFHDDECISTIEYGKQITRDRFDPFDESGNMFWGGTHLLMQLKKYA- 201

  Fly    75 SIAEMPRRRLLLEWQPNDSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTR 139
            |:.:......|....|:....:|..|.:      :.::....|..|     ::.|..|...::..
pombe   202 SLEQSSHESQLYLVNPSPEDTVAFQSVE------LQKVISNNRLNS-----SSTPPTPRSSSSIF 255

  Fly   140 SRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFVRSMRDQHLIENAETSRS 204
            :...|| |.|||...:.      ||.|          ...:|.::: .|.|  :|.:..:.....
pombe   256 NPFRRA-LHDLSFTVLE------RFSR----------VTNYGKSEV-DRLM--EHKVTKSILPHL 300

  Fly   205 GGEVYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSPKSRP 269
            ..|:..:|  |:::::|...|.|         |...:|.....||:
pombe   301 PRELQVLL--ESKRVQKLTEEYD---------PARMFLARWAEGIV------------------- 335

  Fly   270 GVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDR 334
                   .|:..:|.|.:..:|....|......|.|        ..||..:             .
pombe   336 -------EQSESNNSQPVNNAGVWTDAQREEDSSLG--------PFELVYI-------------E 372

  Fly   335 QRVERGHPLTETQWLEFQTPDGRIS-DSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVER 398
            :||:|..||:..||.......|::. |..|:..:||.||:..|||.|||.|||:.|.|..|..||
pombe   373 ERVKRDDPLSVEQWNSMFNAHGKLQVDVHRVLGIIFHGGIQPSLRKEVWPFLLSVYPWDSTSEER 437

  Fly   399 IERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGED-------- 455
            .........||..:|.:|.. ...::.|...:.|::.:|||||.||||..::|..||
pombe   438 RVIYLSLQEEYCTLKRKWYE-DIHKQFNDRWFIEQRNRIEKDVHRTDRQHEYFQIEDLPHPDPQS 501

  Fly   456 -----NPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFD 515
                 |.|:.:::.||:||..|:.:||||||||||||||.....:...|||..||.|:.:..||.
pombe   502 TFTGTNMNMEMMKDILLTYNEYDTELGYVQGMSDLLAPIYVTFNDNALTFWGMVGLMKRLHFNFL 566

  Fly   516 IDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWT 580
            .||:||..|...:|.||||.:..||.::...||.|::..||.||:::|||.:.|.:||||:.|:|
pombe   567 RDQSGMHRQLDTLRLLIEFMDPELFAHLEKTDSSNLFCFFRMLLIYFKREFDWEVLLKLWDVLFT 631

  Fly   581 RLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQLKGSET 645
            .....::|:..:.||.::...|:::....|.|:||:.|||||.:.::.||..||..:.|.|..
pombe   632 NYLSYDYHIFVAYAIAERHREVLLNQTSAFDEVLKYFNELSGKLALEPTLICAEQCFYQFKNK-- 694

  Fly   646 LPNDIRSIIGEPLLPAAAGEEIDGGMVDEEPT 677
                 .::|....:.....:| ||....:.||
pombe   695 -----LALIDRKQMEETNSDE-DGSKETDLPT 720

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	29/168 (17%)
		TBC	369..598	CDD:214540	96/241 (40%)
gyp7	NP_592900.1	DUF3548	31..229	CDD:192931	16/91 (18%)
		COG5210	154..739	CDD:227535	179/672 (27%)
		TBC	408..655	CDD:214540	97/247 (39%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	159	1.000	Domainoid score	I999
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002107
OrthoInspector	1	1.000	-	-		oto101436
orthoMCL	1	0.900	-	-		OOG6_101355
Panther	1	1.100	-	-	LDO	PTHR22957
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2140
SonicParanoid	1	1.000	-	-		X1395
TreeFam	1	0.960	-	-
	11	10.800