DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and Tbc1d8b

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_001074968.1	Gene:	Tbc1d8b / 245638	MGIID:	1918101	Length:	1114	Species:	Mus musculus

Alignment Length:	665	Identity:	129/665 - (19%)
Similarity:	238/665 - (35%)	Gaps:	194/665 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   145 AQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGN---------ADLFVRSMRDQHLIEN-- 198
            ::||..|:|.:.   ::|....:|.|  |....|.|.|         |:..::.:.|:...:|
Mouse   206 SKLEKTSTVILT---ESIHVCSQGEN--HYFSMFLHINETYLLMEQLANYAIKRLFDKETFDNDP 265

  Fly   199 -----AETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRES----------WLP----- 243
                 .:.::.|.|..|    .:::.|..|           :||:|.          |:|
Mouse   266 VLDDPLQITKRGLEYRA----HSEQFKAFF-----------RLPKEETLKEVHECFLWVPFSHFS 315

  Fly   244 --NKL---------AGILGNIPDYVQP-----PFQRSPKSRPGVLISGDRQTS------PDNYQI 286
              .|:         |...||:...:.|     ...::..|...|:||...:|:      .|..|:
Mouse   316 SHGKMCISENYICFASQDGNLCSVIIPLREVLAIDKTDDSNRSVIISIKGKTAFRFSELKDFEQL 380

  Fly   287 IGL------------SGSTNSACSSNGQSRGGSAEKSPADSELE---TLNAQ------DEKIVNN 330
            :..            ..||..|.||:......:.|:.|.....|   |:|.:      ..:.:.|
Mouse   381 VAKLRLKCRAASTQDDVSTEVAVSSDSTGPSENFEEQPLTCPKECSKTVNTEALMTVFHPQNLEN 445

  Fly   331 LPDRQRVERGHPLTETQWLEFQTPDGR---ISDSARIKELIFRGGVVQSLRPEVWKFLL------ 386
            |..:...|:   :.|..|....:..||   :..:.:.::|:.| |:.::||.|:|....
Mouse   446 LDSKMLKEK---MKEQSWNILFSECGRGVSMFRTKKTRDLVVR-GIPETLRGELWMLFSGAVNDM 506

  Fly   387 ----NYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRS 447
                .||      .|.:|    :|:...|:..:                    :||:|::   ||
Mouse   507 ATNPGYY------AEVVE----QSLGTSNLATE--------------------EIERDLR---RS 538

  Fly   448 L-QFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVF 511
            | :..|.:.:..::.|:.:|..|...|..:||.|.| ::|..:|.:...|.:.||..|...|.:.
Mouse   539 LPEHPAFQSDTGISALRRVLTAYAYRNPKIGYCQAM-NILTSVLLLYAKEEEAFWLLVAVCERML 602

  Fly   512 TNFD--------IDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYF---CFRWLLVWYKRE 565
            .::.        :|||    .|.::.|    .:.|   .:..|.:|..:|   ...|.|..:...
Mouse   603 PDYFNRRIIGALVDQA----VFEELIR----DHLP---QLTDHMTDMTFFSSVSLSWFLTLFISV 656

  Fly   566 LNSEDVLKLWECLWTRLPCPNFH------LLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNI 624
            |..|..:.:.:|.        |:      |...:||||.....::..: :..|.:..:|....|:
Mouse   657 LPIESAVNVVDCF--------FYDGIKAILQLGLAILDYNLDKLLTCK-DDAEAVTALNRFFDNV 712

  Fly   625 ---DVQKTLQVAEGIYLQLKGSETLPNDIRSIIGEPLLPAAAGEEIDGGMVDEEPTYSDDGFDEL 686
               |......|.:|..:..:.|:....||..:|.|      :.|:.  |.:..|..:|....:.|
Mouse   713 INKDSPLPSNVQQGSNISNEKSDHTKVDITDLIKE------SNEKY--GSIRYEDIHSMRCRNRL 769

  Fly   687 VKELTPEEKVRQQAL 701
            ....|.||..:|..|
Mouse   770 YVIQTLEETTKQNVL 784

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	12/54 (22%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	53/256 (21%)
Tbc1d8b	NP_001074968.1	PH-GRAM1_TBC1D8B	156..254	CDD:275419	12/52 (23%)
		PH-GRAM2_TBC1D8B	296..388	CDD:270159	15/91 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..420		6/20 (30%)
		TBC	485..693	CDD:214540	54/261 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	938..957
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1032..1061
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900