DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and RABGAP1

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_036329.3	Gene:	RABGAP1 / 23637	HGNCID:	17155	Length:	1069	Species:	Homo sapiens

Alignment Length:	840	Identity:	176/840 - (20%)
Similarity:	297/840 - (35%)	Gaps:	224/840 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SVRYDRCHQVQLGVFNESQLSSVEEDVQNL--PQQGTG-------NILFT---HDGV-------- 48
            |:...:| |:.|.|  ...:.:|.|.:..|  ||..|.       .|||.   |||.
Human   172 SILRSQC-QISLDV--TLSVPNVSEGIVRLLDPQTNTEIANYPIYKILFCVRGHDGTPESDCFAF 233

  Fly    49 LLKKASAE----HIADLNTSGSLSLVEYS------RSIAEMPRRRLLLEWQPND-------SIMI 96
            .....:||    |:.......::|.:.||      ||..:.|.........|:.       |:.|
Human   234 TESHYNAELFRIHVFRCEIQEAVSRILYSFATAFRRSAKQTPLSATAAPQTPDSDIFTFSVSLEI 298

  Fly    97 ADDSQDQGDWALVDRISGR-----------------TRTTSE------CRAFNTRPIEPSGGATT 138
            .:| ..:|.::.|.:...|                 .:||::      |......|     |...
Human   299 KED-DGKGYFSAVPKDKDRQCFKLRQGIDKKIVIYVQQTTNKELAIERCFGLLLSP-----GKDV 357

  Fly   139 RSRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNAD------LFVRSMRDQHLIE 197
            |:..|  .|.||.|:.....|::  ::..|:....|. .||..|.:      ||:.:..|..:.|
Human   358 RNSDM--HLLDLESMGKSSDGKS--YVITGSWNPKSP-HFQVVNEETPKDKVLFMTTAVDLVITE 417

  Fly   198 NAETSRSGGEVYAILTTENQKL-----KKTFAE---LDIGQIKASQLPRESWLPNKLAGILGNIP 254
            ..|..|...|....:.:.|::|     |::..|   |.:.|||
Human   418 VQEPVRFLLETKVRVCSPNERLFWPFSKRSTTENFFLKLKQIK---------------------- 460

  Fly   255 DYVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSG-------STNSACSSNGQSRGGSAEKSP 312
                   ||..|:....|           |:::.|..       .|.::.|......|..:...|
Human   461 -------QRERKNNTDTL-----------YEVVCLESESERERRKTTASPSVRLPQSGSQSSVIP 507

  Fly   313 ADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKEL--IFRGGVVQ 375
            :..|.:.....||.:::...|..: |....:.|| |.|..: ...::.:.|.|:|  :.|.||.:
Human   508 SPPEDDEEEDNDEPLLSGSGDVSK-ECAEKILET-WGELLS-KWHLNLNVRPKQLSSLVRNGVPE 569

  Fly   376 SLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKD 440
            :||.|||:.|...:  ::.|:          :|.|.       :..|:|:      .:...|.:|
Human   570 ALRGEVWQLLAGCH--NNDHL----------VEKYR-------ILITKES------PQDSAITRD 609

  Fly   441 VKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFV- 504
            :.||..:..:|..........|..|...|.:|:.::||.||.| .||.:|.:.:.|...|...|
Human   610 INRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQS-FLAAVLLLHMPEEQAFSVLVK 673

  Fly   505 -----GFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKR 564
                 |..||...||:    .:..:|.|:.||::.....|:|:......:...:..:|.|..:..
Human   674 IMFDYGLRELFKQNFE----DLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFLTLFTA 734

  Fly   565 ELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQET-----------------RVIIDSQYEFTE 612
            :.....|..:.:.|.    |....::|:||:...:|                 ||.:..:|...|
Human   735 KFPLYMVFHIIDLLL----CEGISVIFNVALGLLKTSKDDLLLTDFEGALKFFRVQLPKRYRSEE 795

  Fly   613 ILKHVNELSGNIDV-QKTLQVAEGIYLQLKGSETLPND-IRSIIGEPLLPAAAG---EEIDGGMV 672
            ..|.:.||:.|:.: ||.|:..|..|..::..:....| |.....|......|.   |:.:..:.
Human   796 NAKKLMELACNMKISQKKLKKYEKEYHTMREQQAQQEDPIERFERENRRLQEANMRLEQENDDLA 860

  Fly   673 DEEPT----------YSDDGFDELVKEL---------TPEEKVR---QQALLEEACERSL 710
            .|..|          .:::..|.|.|||         ..|||.|   :.|.|:|.|.|.|
Human   861 HELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEEEKRRLEEESAQLKEMCRREL 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	42/217 (19%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	53/234 (23%)
RABGAP1	NP_036329.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..79
		PTB_Rab6GAP	145..273	CDD:269922	25/103 (24%)
		DUF3694	307..437	CDD:403614	26/139 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..527		7/44 (16%)
		TBC	563..772	CDD:214540	54/242 (22%)
		Smc	<823..>1047	CDD:224117	22/98 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810