DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and TBC1D12

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_056003.1	Gene:	TBC1D12 / 23232	HGNCID:	29082	Length:	775	Species:	Homo sapiens

Alignment Length:	658	Identity:	146/658 - (22%)
Similarity:	234/658 - (35%)	Gaps:	138/658 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 DLNTSGSLSLVEYSRSIAEMPRRRLLLEWQPNDSIMIADDSQDQGDWA--LVDRISGRTRTTSEC 122
            ||..:..|:......|....|..||.|| .|.|.  .||.:....|||  |.|.:.......::.
Human   148 DLEEARGLARAGGRESRRRRPYGRLRLE-GPGDE--DADGAGSPSDWASPLEDPLRSCCLVAADA 209

  Fly   123 RAFNTRPIEPSGGATTRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGA---------NG------V 172
            :       ||.|..:.......:...  ||.:...||.......:||         ||      .
Human   210 Q-------EPEGAGSDSGDSPASSCS--SSEDSEQRGVGAGGPEEGAPPATSAERTNGGAEPRLG 265

  Fly   173 HSEFFFQHGNADLFVR--SMRDQHLI-----------------ENAETSRSGGEVYAILTTENQK 218
            .|:..|...|.....|  |.|| ||.                 .:|...||||  :|...|.|..
Human   266 FSDIHFNSRNTFQVSRGQSARD-HLPPAGPPVPLPAAEQGPAGASARARRSGG--FADFFTRNLF 327

  Fly   219 LKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIP--DYVQPP---FQRSPKSRPGVLISGDRQ 278
            .|:|      .::|:.......|      .:.|.:|  :.:|..   .|:..::|.|.......|
Human   328 PKRT------KELKSVVHSAPGW------KLFGKVPPRENLQKTSKIIQQEYEARTGRTCKPPPQ 380

  Fly   279 TS-PDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDE----------KIVNNLP 332
            :| ..|::...|  ||.:....:..|      ..||.|..|.|..:.|          :.:....
Human   381 SSRRKNFEFEPL--STTALILEDRPS------NLPAKSVEEALRHRQEYDEMVAEAKKREIKEAH 437

  Fly   333 DRQRVERGHPLTETQ-------WLEFQTPDGRISDSA-RIKELIFRGGVVQSLRPEVWKFLLNYY 389
            .|:|:.:.....|..       |:....|:..:..|. |::||.:: |:..|:|.:||...:...
Human   438 KRKRIMKERFKQEENIASAMVIWINEILPNWEVMRSTRRVRELWWQ-GLPPSVRGKVWSLAVGNE 501

  Fly   390 LWSDTHVERIERRKQKSIEYYNM-----KAQWLAMTTTQEAN-----FCGYRERKCQIEK-DVKR 443
            |             ..:.|.|.:     |.:|.:.:.|...|     ....||...::.| |:.|
Human   502 L-------------NITPELYEIFLSRAKERWKSFSETSSENDTEGVSVADREASLELIKLDISR 553

  Fly   444 TDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFM- 507
            |..||..|. :..|...:|..||..|..|..|:||||||| .:|.:|.:.:.|.|.|..|...:
Human   554 TFPSLYIFQ-KGGPYHDVLHSILGAYTCYRPDVGYVQGMS-FIAAVLILNLEEADAFIAFANLLN 616

  Fly   508 ---ELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSE 569
               :|.|  |.:|.:.|...||......|...:.||.:.:|:......:...|:...|.:.|..:
Human   617 KPCQLAF--FRVDHSMMLKYFATFEVFFEENLSKLFLHFKSYSLTPDIYLIDWIFTLYSKSLPLD 679

  Fly   570 DVLKLWECLWTRLPC---PNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQ 631
            ...::|:..     |   ..|.....:.||.....:::  |.:|..|.:.:.:|..:|..:|...
Human   680 LACRVWDVF-----CRDGEEFLFRTGLGILRLYEDILL--QMDFIHIAQFLTKLPEDITSEKLFS 737

  Fly   632 VAEGIYLQ 639
            ....|.:|
Human   738 CIAAIQMQ 745

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	34/149 (23%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	60/246 (24%)
TBC1D12	NP_056003.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..66
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	94..312		39/176 (22%)
		TBC	481..712	CDD:214540	60/253 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810