DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and TBC1D9

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_055945.2	Gene:	TBC1D9 / 23158	HGNCID:	21710	Length:	1266	Species:	Homo sapiens

Alignment Length:	782	Identity:	144/782 - (18%)
Similarity:	263/782 - (33%)	Gaps:	274/782 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 DVQNLPQQGTGNILFTHDGVLLKKASAEHIAD--LNTSGSLSLVEYSRSIAEMPRRRLLLEWQPN 91
            |:..|.:..|   |...|.:.:...|:||...  ||.:.:..|:|   .:|.:..|:||    .|
Human   205 DITQLEKNAT---LLLPDVIKVSTRSSEHFFSVFLNINETFKLME---QLANIAMRQLL----DN 259

  Fly    92 DSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTRSRVMRAQLEDLSSVEVR 156
            :..     .||              |:..:.:..:.:.:    .|..|....||:.|       |
Human   260 EGF-----EQD--------------RSLPKLKRKSPKKV----SALKRDLDARAKSE-------R 294

  Fly   157 HRGQTIRFMRKGANGVHSE------FFFQHGNADLFVRS------------------MRDQHLIE 197
            :|. ..|..:......|::      |...|....:||.:                  :|:..::|
Human   295 YRA-LFRLPKDEKLDGHTDCTLWTPFNKMHILGQMFVSTNYICFTSKEENLCSLIIPLREVTIVE 358

  Fly   198 NAETSRSGGEVYAILTTENQKLKKTFAEL-----------DIGQIKASQLPRESWLPNKLAGILG 251
            .|::|.......:|.|  ..::...||.|           |..|...|::    :...:.||...
Human   359 KADSSSVLPSPLSIST--RNRMTFLFANLKDRDFLVQRISDFLQQTTSKI----YSDKEFAGSYN 417

  Fly   252 NIPDYVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSE 316
            :..|.|.        |||..|:|...|.|                            ..|.||.|
Human   418 SSDDEVY--------SRPSSLVSSSPQRS----------------------------TSSDADGE 446

  Fly   317 LE-TLNAQDEKIVNNLPD----------RQRVERGHPLTETQWLEFQTPDGRISD---------S 361
            .: .||.      |::|.          |:..|..:|....::|:.|......::         :
Human   447 RQFNLNG------NSVPTATQTLMTMYRRRSPEEFNPKLAKEFLKEQAWKIHFAEYGQGICMYRT 505

  Fly   362 ARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEAN 426
            .:.:||:.: |:.:|:|.|:|..|........||....|...:||:..||:..:
Human   506 EKTRELVLK-GIPESMRGELWLLLSGAINEKATHPGYYEDLVEKSMGKYNLATE----------- 558

  Fly   427 FCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILE 491
                     :||:|:.|:......|..|  ..:..|:.:|..|...|.::||.|.| :::..:|.
Human   559 ---------EIERDLHRSLPEHPAFQNE--MGIAALRRVLTAYAFRNPNIGYCQAM-NIVTSVLL 611

  Fly   492 IQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFR 556
            :...|.:.||..|...|                    |.|.::.|..:...:    .|...|
Human   612 LYAKEEEAFWLLVALCE--------------------RMLPDYYNTRVVGAL----VDQGVF--- 649

  Fly   557 WLLVWYKRELNSEDVLKLWECL------------WTRLPCPNFHLLFSVAILDQETRVIIDSQYE 609
                   .||..:.|.:|::|:            |       |..|| ::::..|:.|::...:
Human   650 -------EELARDYVPQLYDCMQDLGVISTISLSW-------FLTLF-LSVMPFESAVVVVDCF- 698

  Fly   610 FTEILKHVNELS-----GNIDVQKTLQVAE--------GIYLQ--LKGSETLP--NDIRSIIGEP 657
            |.|.:|.:.:|:     .|:|  |.|...:        |.||.  .....|||  ..:.|::.:
Human   699 FYEGIKVIFQLALAVLDANVD--KLLNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSD- 760

  Fly   658 LLPAAAGEEIDGGMVDEEPTYSDDGF--------------DELVKELTPEEKVRQQALLEEACER 708
                           |.||....|.|              .:|::::..:::::....||:..:|
Human   761 ---------------DVEPYPEVDIFRLIRTSYEKFGTIRADLIEQMRFKQRLKVIQTLEDTTKR 810

  Fly   709 SL 710
            ::
Human   811 NV 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	31/179 (17%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	47/240 (20%)
TBC1D9	NP_055945.2	PH-GRAM1_TCB1D9_TCB1D9B	157..255	CDD:275420	13/55 (24%)
		PH-GRAM2_TCB1D9_TCB1D9B	304..399	CDD:270161	15/96 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..456		16/82 (20%)
		TBC	512..722	CDD:214540	56/278 (20%)
		EFh	<893..923	CDD:385324
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1075..1095
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1132..1164
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900