Protein Alignment Tbc1d15-17 and TBC1D9B

DIOPT Version :9

• Sequence 1: NP_001259806.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_942568.2
• Gene: TBC1D9B / 23061
• HGNCID: 29097
• Length: 1250
• Species: Homo sapiens
• Alignment Length: 702
• Identity: 140/702 - (19%)
• Similarity: 265/702 - (37%)
• Gaps: 180/702 - (25%)

  Fly    61 LNTSGSLSLVEYSRSIAEMPRRRLLLEWQPNDSIMIADDSQDQGDWALVDRISGRTRTTSECRAF 125
            ||...:..|:|   .:|.:..|:||      ||....:|.      ||
Human   232 LNIGETFKLME---QLANLAMRQLL------DSEGFLEDK------AL----------------- 264

  Fly   126 NTRPIEPSGGATTRSRVM--RAQLEDLSSV-----EVRHRGQTIRFMRKGANGVH--SEFFFQHG 181
             .|||.|....:...|.:  ||:.|...:.     :.|..|.|...:....|.:|  .:.|..:.
Human   265 -PRPIRPHRNISALKRDLDARAKNECYRATFRLPRDERLDGHTSCTLWTPFNKLHIPGQMFISNN 328

  Fly   182 ---------NADLFVRSMRDQHLIENAETSRSGGEVYAILTTENQKLKKTFAEL---DIGQIKAS 234
                     :|...:..:|:..::|.|::|.......:|.|  ..|:...||.|   |....:.|
Human   329 YICFASKEEDACHLIIPLREVTIVEKADSSSVLPSPLSIST--KSKMTFLFANLKDRDFLVQRIS 391

  Fly   235 QLPRESWLPNKLAGILGN-IPDYVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACS 298
            ...:::  |:|..|.:|: ....|.|..:.||..:.|    .::..||.:    .|| |..|.|:
Human   392 DFLQKT--PSKQPGSIGSRKASVVDPSTESSPAPQEG----SEQPASPAS----PLS-SRQSFCA 445

  Fly   299 SNGQSRG-GSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGR---IS 359
            ....:.. |..:....:|.:|.|.|:..|      ::.:.|..|    ..:.|:    ||   :.
Human   446 QEAPTASQGLLKLFQKNSPMEDLGAKGAK------EKMKEESWH----IHFFEY----GRGVCMY 496

  Fly   360 DSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSD--THVERIERRKQKSIEYYNMKAQWLAMTTT 422
            .:|:.:.|:.: |:.:|||.|:|  ||....|::  ||........:||...|::..:
Human   497 RTAKTRALVLK-GIPESLRGELW--LLFSGAWNEMVTHPGYYAELVEKSTGKYSLATE------- 551

  Fly   423 QEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLA 487
                         :||:|:.|:......|..|  ..:..|:.:|..|...|..:||.|.| :::.
Human   552 -------------EIERDLHRSMPEHPAFQNE--LGIAALRRVLTAYAFRNPTIGYCQAM-NIVT 600

  Fly   488 PILEIQVNEVDTFWCFVGFMELVFTNFD--------IDQAGMKTQFAQIRRLIEFANAPLFNYMR 544
            .:|.:..:|.:.||..|...|.:..::.        :|| |:   |.::.|  :|  .|..
Human   601 SVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQ-GI---FEELTR--DF--LPQL---- 653

  Fly   545 SHDSDNMY-------FCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRV 602
               |:.|.       ....|.|..:...:..|..:.:.:|.:..          .:.::.|....
Human   654 ---SEKMQDLGVISSISLSWFLTLFLSVMPFESAVVIVDCFFYE----------GIKVILQVALA 705

  Fly   603 IIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYL-----QLKGSETLPNDIRSIIGEPLLPAA 662
            ::|:..|         :|.|..|..:.:.:. |.||     :...|..:|: :|:::.....|.|
Human   706 VLDANME---------QLLGCSDEGEAMTML-GRYLDNVVNKQSVSPPIPH-LRALLSSSDDPPA 759

  Fly   663 AGEEIDGGMVDEEPTYSDDGFDEL----VKELTPEEKVRQQALLEEACERSL 710
               |:|   :.|....|.:.|..|    ::::..:::::....||:..:||:
Human   760 ---EVD---IFELLKVSYEKFSSLRAEDIEQMRFKQRLKVIQSLEDTAKRSV 805

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	28/147 (19%)
		TBC	369..598	CDD:214540	47/245 (19%)
TBC1D9B	NP_942568.2	PH-GRAM1_TCB1D9_TCB1D9B	153..251	CDD:275420	5/21 (24%)
		PH-GRAM2_TCB1D9_TCB1D9B	299..394	CDD:270161	19/96 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	397..443		14/56 (25%)
		TBC	505..715	CDD:214540	50/269 (19%)
		EFh	<855..906	CDD:298682
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	974..999
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1069..1093
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1128..1157

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810