Protein Alignment Tbc1d15-17 and Rabgap1

DIOPT Version :9

• Sequence 1: NP_001259806.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001349885.1
• Gene: Rabgap1 / 227800
• MGIID: 2385139
• Length: 1064
• Species: Mus musculus
• Alignment Length: 602
• Identity: 130/602 - (21%)
• Similarity: 224/602 - (37%)
• Gaps: 125/602 - (20%)

  Fly   192 DQHLIENAETSRSG-GEVYAILTTENQK-----------------LKKTFAELDIGQIKASQLPR 238
            |.||::.....:|. |:.|.|..:.|.|                 ...|..:|.|.::   |.|.
Mouse   356 DMHLLDLESMGKSSDGKSYVITGSWNPKSPHFQVVNEETPKDKVLFMTTAVDLVITEV---QEPV 417

  Fly   239 ESWLPNKLAGILGNIPDYVQPPF-QRSPKSRPGVLISGDRQTSPDN-----YQIIGLSG------ 291
            ...|..|:.....|  :.:..|| :||......:.:...:|....|     |:::.|..
Mouse   418 RFLLETKVRVCSPN--ERLFWPFSKRSTTENFFLKLKQIKQKEKKNNADTLYEVVCLESESERER 480

  Fly   292 -STNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPD 355
             .|.::.|......|..:...|:..|.:.....||.:::...|..: |....:.|| |.|..: .
Mouse   481 RKTTASPSVRLPQSGSQSSMIPSPPEDDEEEDNDEPLLSGFGDVSK-ECAEKILET-WGELLS-K 542

  Fly   356 GRISDSARIKEL--IFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLA 418
            ..::.|.|.|:|  :.|.||.::||.|||:.|...:  ::.|:          :|.|.
Mouse   543 WHLNLSVRPKQLSSLVRSGVPEALRGEVWQLLAGCH--NNDHL----------VEKYR------- 588

  Fly   419 MTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMS 483
            :..|:|:      .:...|.:|:.||..:..:|..........|..|...|.:|:.::||.||.|
Mouse   589 ILITKES------PQDSAITRDINRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQS 647

  Fly   484 DLLAPILEIQVNEVDTFWCFV------GFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNY 542
             .||.:|.:.:.|...|...|      |..||...||:    .:..:|.|:.||::.....|:|:
Mouse   648 -FLAAVLLLHMPEEQAFSVLVKIMFDYGLRELFKQNFE----DLHCKFYQLERLMQEYIPDLYNH 707

  Fly   543 MRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQET------- 600
            ......:...:..:|.|..:..:.....|..:.:.|.    |....::|:||:...:|
Mouse   708 FLDISLEAHMYASQWFLTLFTAKFPLYMVFHIIDLLL----CEGISVIFNVALGLLKTSKDDLLL 768

  Fly   601 ----------RVIIDSQYEFTEILKHVNELSGNIDV-QKTLQVAEGIYLQLKGSETLPND-IRSI 653
                      ||.:..:|...|..|.:.||:.|..: ||.|:..|..|..::..:....| |...
Mouse   769 TDFEGALKFFRVQLPKRYRSEENAKRLMELACNTKISQKKLKKFEKEYHTMREQQAQQEDPIERF 833

  Fly   654 IGEPLLPAAAG---EEIDGGMVDEEPT----------YSDDGFDELVKEL---------TPEEKV 696
            ..|......|.   |:.:..:..|..|          .:::..|.|.|||         ..:||.
Mouse   834 ERENRRLQEANMRLEQENDDLAHELVTSKIALRKDLDNAEEKADALNKELLMTKQKLIDAEDEKR 898

  Fly   697 R---QQALLEEACERSL 710
            |   :.|.|:|.|.|.|
Mouse   899 RLEEESAQLKEMCRREL 915

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
		TBC	369..598	CDD:214540	53/234 (23%)
Rabgap1	NP_001349885.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..101
		PTB_Rab6GAP	140..268	CDD:269922
		DUF3694	302..432	CDD:315198	17/80 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	478..520		7/41 (17%)
		TBC	558..767	CDD:214540	54/242 (22%)
		ERM	789..1013	CDD:330563	31/127 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810