DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and tbc-19

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_510336.3	Gene:	tbc-19 / 181511	WormBaseID:	WBGene00007849	Length:	1333	Species:	Caenorhabditis elegans

Alignment Length:	685	Identity:	144/685 - (21%)
Similarity:	240/685 - (35%)	Gaps:	167/685 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LFTHDGVLLKKASAEHIADLNTSGSLSLVEYSRSIAEMPRRRLLLEWQPNDSIMIADD------- 99
            :.||..:  ||||:....:..|:.:...:.:.:.  .:|.:.|:   ...:.||...|
Worm   123 MMTHRKI--KKASSLPDQESTTAATDQHIPFRKH--SVPAQNLV---TTRNFIMPPPDIAEGYLP 180

  Fly   100 SQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTRSRVMRAQLEDLSSV----------- 153
            .::..||......:.:......|....|..........|.|...||:.|:|..:
Worm   181 DEEMDDWVTQWLTNEKFHNFPSCTDMTTPTSTNQSKVDTCSESERAESEELDLLREITNNQKKKI 245

  Fly   154 -EVRH--RGQTIRF--MRKGA---NG------------VHSEFFFQHGNADLFV-------RSMR 191
             :::|  ...|:..  |||.|   ||            ::||........::..       :|.|
Worm   246 EDMKHEMNAMTLHIDQMRKRADSTNGTDRDTLSAQNKFLNSEILRMSAKCEILTMQSSGNRKSHR 310

  Fly   192 D-QHLIENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPD 255
            : :.|.|..:..|. ..||||.:|....|....| :|:..:|                :||.
Worm   311 ENKRLTEELQLLRC-DYVYAIQSTIRIPLHDNTA-MDVMSVK----------------LLGG--- 354

  Fly   256 YVQPPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETL 320
                   .:.|||...|::..||..|....:..|         ..|........:.....|...|
Worm   355 -------ETHKSRLIQLMAEARQHDPSLPTLQSL---------LQGIYVDSFGFRISFKEEPNAL 403

  Fly   321 NAQDEKIVNNLPDRQRVERGHPLTETQWLEFQ-----TPDGRISDSARIKELIFRGGVVQSLRPE 380
            :....|:.:...:|.:....|.....::||..     ||:.:|         :.|.|:..|||..
Worm   404 HYMATKLNHFYANRSKSASEHKYNWKRFLEENDFIDLTPETKI---------MCRKGIPNSLRAT 459

  Fly   381 VWKFLLNYYLWSDTHVERIERRKQKSIEYY--NMKAQWLAMTTTQEANFCGYRERKC-------Q 436
            |||.|:|         :::|..|....:||  |:            .|..|..:.|.       |
Worm   460 VWKILIN---------QQVEDLKNVYGKYYYRNL------------CNIQGGEDEKTYSDVHQKQ 503

  Fly   437 IEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFW 501
            |..|:.||..:...|...::..:|.|..:|..:.::|..:||.|||:.|.|..| :.|...|.||
Worm   504 INLDLLRTMPNNVHFMSANSKGVTQLLQVLHAFCLHNSQIGYCQGMNFLAATAL-LFVGPEDAFW 567

  Fly   502 CFVGFMELVF--TNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKR 564
            ..:...|..|  |.||.:..|.:.....::.|:|..:..:..:::|.|.|...|...|.:..:..
Worm   568 FLIAVTERYFDKTYFDSNLTGAQADQEVLKGLLEVQHPKIMKHLKSLDIDVASFTLNWFISLFFD 632

  Fly   565 ELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKT 629
            .:....:|::|:|.....|    .:||..||      |:|.         ||..|:....|
Worm   633 AVPFNTLLRIWDCFLLEGP----KVLFRFAI------VLIG---------KHEEEIISRGD---- 674

  Fly   630 LQVAEGIYLQLKGSETLPNDIRSIIGE----PLLP 660
               |.||....|.:..|..|..:|:..    |.||
Worm   675 ---AIGIMRVSKAATKLAFDEEAIVNMAFRIPNLP 706

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	33/193 (17%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	61/239 (26%)
tbc-19	NP_510336.3	PH-like	13..112	CDD:302622
		PH	16..110	CDD:278594
		TBC	448..670	CDD:214540	66/262 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810