DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and tbc-18

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	NP_509421.2	Gene:	tbc-18 / 181091	WormBaseID:	WBGene00018281	Length:	826	Species:	Caenorhabditis elegans

Alignment Length:	504	Identity:	100/504 - (19%)
Similarity:	200/504 - (39%)	Gaps:	101/504 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   215 ENQKLKKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSPKSRPGVLISGDRQT 279
            ::|::..::.|||.....|.         ||     ..:|.|::.|.:...:       .|.|:.
Worm    36 KDQEIHSSYFELDGKPFSAI---------NK-----AMLPIYIEDPLEFFDE-------FGFRKQ 79

  Fly   280 SPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLT 344
            ..|:...:|....|:||          .....|.::....|     |:::.|.|..:..:...|
Worm    80 DDDHDPNLGDEEETSSA----------KHLSEPLENSTHKL-----KLISYLQDVHKEVKDDVL- 128

  Fly   345 ETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEY 409
               |.....|:.:   :.|.:||:..||:..|:||.:|..|..            ..:|||..:|
Worm   129 ---WSHILGPELK---TDRFEELLKEGGIPHSMRPFLWPRLSG------------ATKKQKDAKY 175

  Fly   410 -YNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYN 473
             |....|..|    |:....|     .|||:|:.||..:...|..:::..:..|:.||.......
Worm   176 TYESVLQQCA----QDKPSIG-----VQIERDLLRTLPNNICFWKKNSEGIEALRRILKCVAFIY 231

  Fly   474 FDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFME-LVFTNFDIDQ-AGMKTQFAQIRRLIEFAN 536
            .||||.|||..::|.:| :..:|..|||.....:| ::..||.... .|::......|.|::...
Worm   232 PDLGYCQGMGVIVATLL-LYCSEETTFWMMTALIEDILPPNFYTQTLLGLQADERVSRHLMKCHV 295

  Fly   537 APLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSV-AILDQET 600
            ..|...:..::.:.......|||..:.....:..:|::|:.::.......|.::.|: .:.:||.
Worm   296 PDLNKALEDYEVEVSLLTVSWLLTLFGSVFRTRVMLRVWDFIFYSGGVNIFRVIISILKMKEQEI 360

  Fly   601 RVIIDSQYEFTEILKHVNELSGNI-DVQKTLQ--------VAEGIYLQLKGSETLPNDIRSIIGE 656
            ..|.::.....:|...:::|..:: :|:|.::        :.:.:..:|:...           :
Worm   361 VEIAETTQSSADIFTALSQLPASVTEVEKVIEYMGSFEFTITDHLIAELRKKH-----------Q 414

  Fly   657 PLLPAAAGEEIDGGMVDEEPTYSDDGFDELVKELTPEEKV-RQQALLEE 704
            .:|.|      |.||:....|.::     |.|:.|...|: |.::::::
Worm   415 AVLMA------DQGMIVNTATDTN-----LPKQTTQRRKLTRSKSIIKQ 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	53/232 (23%)
tbc-18	NP_509421.2	TBC	148..361	CDD:214540	55/234 (24%)
		SH3_SGSM3	528..580	CDD:212747
		RUN	607..765	CDD:280855
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810