Protein Alignment Tbc1d15-17 and tbc-16

DIOPT Version :10

• Sequence 1: NP_608503.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_508988.3
• Gene: tbc-16 / 180856
• WormBaseID: WBGene00018639
• Length: 725
• Species: Caenorhabditis elegans
• Alignment Length: 693
• Identity: 172/693 - (24%)
• Similarity: 280/693 - (40%)
• Gaps: 119/693 - (17%)

  Fly    39 GNILFTHDGVLLKKASAEHIAD-LNTSGSLSL---VEYSRSIAEMPRRRLLLEWQPNDSIMIADD 99
            |:::::.:.|.:.:..|:...| .:..|.|::   .:.|..:.      |:|:|.||.::.....
 Worm    30 GDVVYSKNNVCVHETDAKAGEDEAHCPGYLTVHCQCDESMGLT------LILQWLPNLTLQKNPQ 88

  Fly   100 S-----------QDQGDWAL----VDRISGRTRTTSECRAFNTRPIEPSGGATTRSRVMR----- 144
            |           :|:...|:    .|.:.....:..|........||..|.|....:|.|
 Worm    89 SIRSVSPRGKQNRDENGQAMPAKPADEVKVSLLSDEESSVSLDIQIEECGTAVPVKQVKRPTTLV 153

  Fly   145 --AQLEDLS--------SVEV------RHRGQTIRFMR-KGANGVHSEFFFQHGNADLFVRSMRD 192
              .|.||.|        |:.|      :|....||... |..:...|:.......||    .|.|
 Worm   154 PYGQQEDHSFNDALGVPSINVIPHTPIKHENNEIRTENAKDESDKMSQSSLSTSCAD----EMSD 214

  Fly   193 QHLI------ENAETSRSGGEVYAILTTENQKLKKT---FA---ELDIGQIKASQLPRESWLPNK 245
            :.|.      ::.|....|..:..||.: .|...||   ||   :|.:...|::....:|....|
 Worm   215 KELSSSEDGDDDCEKPDPGVGLEKILES-TQMFDKTPEQFALEHDLMLTDTKSNDSEEQSRGRKK 278

  Fly   246 LAGI-------LGNIPDYVQPPFQRSPKSRPGVLISGDRQTSPDNYQII-----GL--------S 290
            .||.       ||.:..  ...|..:.:...|.|:..   |...:|:|:     ||        .
 Worm   279 AAGTTSLFSVNLGKMRS--MRVFYSNTECTSGQLVIA---TLDSHYKILHFHHGGLDKLAYIFEQ 338

  Fly   291 GSTNSACSSNGQSRGGSAEK-----SPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLE 350
            .|:..|.|....|....|:|     .||.:::|    :|       |:....|:   :|...|..
 Worm   339 WSSIKARSVQEGSPSAIADKQLIICQPAVTKVE----KD-------PEEGLFEK---ITLNTWRS 389

  Fly   351 FQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQ 415
            ::...|.|.||..:::.||...:...:|.:||.|||..|.|..:..:|...:....:||.|::.:
 Worm   390 YENKSGVIIDSGTVRKHIFFASMDVEMREKVWPFLLRVYPWESSADQRENIKNDLFLEYQNIRKR 454

  Fly   416 WLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQ 480
            ...:|...:|.:.....   .|.|||.||||...||||::|||..:::.||:.|.:...|:.|:|
 Worm   455 RYRVTENAQARWISIEN---SIVKDVVRTDRKNPFFAGDNNPNSEIMKNILLNYAVMYPDINYIQ 516

  Fly   481 GMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAG----MKTQFAQIRRLIEFANAPLFN 541
            ||||||||:|....:|||:::||..||:.  |.|.....|    |:|....:|.::.......:.
 Worm   517 GMSDLLAPLLSTLKDEVDSYFCFKNFMQQ--TVFSSTPQGNENLMETNLTYLRNMLRMFVPDFYE 579

  Fly   542 YMRSHDSDNMYFCF--RWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVII 604
            ::.....|.|...|  ||:|:.:|||......|.:|||.|.......|||...|||:....:.::
 Worm   580 HLEKQRPDAMQLMFVHRWILLCFKREFPENYALHIWECCWAHYRTNYFHLFVCVAIVSIYGKDVL 644

  Fly   605 DSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQLKGSETLP 647
            .......|||.....|:.::|....||.|.|:..:....|.:|
 Worm   645 TQDLPHDEILLFFASLANHMDATLVLQKARGLLFEFTRMEKIP 687

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_608503.1	TBC	369..598	CDD:214540	78/234 (33%)
tbc-16	NP_508988.3	PH_RBD	32..>112	CDD:432305	14/85 (16%)
		TBC	415..644	CDD:214540	77/233 (33%)