Protein Alignment Tbc1d15-17 and tbc-14

DIOPT Version :10

• Sequence 1: NP_608503.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001317776.1
• Gene: tbc-14 / 174986
• WormBaseID: WBGene00008444
• Length: 630
• Species: Caenorhabditis elegans
• Alignment Length: 662
• Identity: 228/662 - (34%)
• Similarity: 329/662 - (49%)
• Gaps: 116/662 - (17%)

  Fly    50 LKKASAEHIADLNTSGSLSLVEYSRSIAEMPRRRLLLEWQPNDS-----IMIADDSQDQGDWALV 109
            |.:.|.|:|     .|:||:||.|..:        .:||:|::.     :|.:||    |:..:|
 Worm    48 LGEDSKEYI-----PGTLSIVEKSSGV--------FIEWKPSEDAETSWVMTSDD----GNTEMV 95

  Fly   110 DRISGRTRTTSECR-AFNTRPIEPSGGATTRSRVMRAQLEDLSSVE----VRHRGQ----TIRFM 165
            ...|...:.....| ||:                  ..:.||||..    .|..|.    :||.:
 Worm    96 HARSPEEKQKCGARVAFS------------------MDVNDLSSFRNDEPKRDSGSGGFPSIRLI 142

  Fly   166 -RKGANGVHSEFFFQHGNADLFV----------RSMRDQHLIENAETSRSGGEVYAILTTENQKL 219
             |.|::.|  ..||::.....|:          ||.||.||:             .::..:::.|
 Worm   143 CRDGSSQV--PLFFKNTTTAEFLDRLQGYITLRRSHRDSHLV-------------IVVDQKSEAL 192

  Fly   220 KKTFAELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQPPFQRSPKSRPGVLISGDRQTSPDNY 284
            .|:.:.||......|:..:..:: ..:.| ...|..:||      .:..|.||...|..|..:..
 Worm   193 AKSVSMLDENGDILSRFMQNPYM-TAMTG-FSKITSFVQ------DQVIPSVLNDTDAVTQEEKI 249

  Fly   285 QIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWL 349
            :::      .....:..|.|    ..|.|..|.|.:...:      ||.|..:.|..|:::..|.
 Worm   250 RLM------RELRLAEEQMR----VHSDAAGEFEVVTQLE------LPPRPEIYRELPVSKDLWN 298

  Fly   350 EFQTPDGRISDSARIKEL---IFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYN 411
            .|:..:|.. |..::..|   :||||:...||.|.||.||.|..|.::..:...||.:.:.:|.|
 Worm   299 SFKLSNGSY-DPMKLHHLKMNVFRGGLNAELRKEAWKCLLGYRQWHESDTDFQTRRAELAKQYEN 362

  Fly   412 MKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDL 476
            ||.||:::|..||..|..:.:||..:||||.||||::.||.|:||.||..|..:|||||||||||
 Worm   363 MKKQWMSVTEDQEKRFTKFVKRKSLVEKDVARTDRTVPFFQGDDNVNLVHLHNVLMTYVMYNFDL 427

  Fly   477 GYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFN 541
            ||||||||..:|:|.:..:||||||||||.|||...||:.|||.:|.|..|:|.|:...|..|.|
 Worm   428 GYVQGMSDFASPLLFVMKDEVDTFWCFVGLMELTQKNFETDQAFIKLQMNQLRDLVMIINPKLAN 492

  Fly   542 YMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDS 606
            |:.|..||:|||||||:|||:|||.:..|..||||.||:..|||.|.||..|||||.:|.:|||:
 Worm   493 YLESEKSDDMYFCFRWVLVWFKREFSFLDTCKLWEVLWSGQPCPRFLLLICVAILDSQTNIIIDN 557

  Fly   607 QYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQLKGSET-LPNDIRSI--IGEPLLPAAAGEEID 668
            |:..||||||:|:||.::.|.:.|..||.|:.||..|:. ||..|...  |||..:.::
 Worm   558 QFGLTEILKHINDLSMHLKVDEILTAAEAIFHQLSASQNKLPAHICQYLNIGESAVSSS------ 616

  Fly   669 GGMVDEEPTYSD 680
                :..|:.||
 Worm   617 ----NNSPSKSD 624

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_608503.1	TBC	369..598	CDD:214540	124/228 (54%)
tbc-14	NP_001317776.1	TBC	320..555	CDD:214540	126/234 (54%)