DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and TBC1D21

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006720472.1	Gene:	TBC1D21 / 161514	HGNCID:	28536	Length:	399	Species:	Homo sapiens

Alignment Length:	329	Identity:	78/329 - (23%)
Similarity:	144/329 - (43%)	Gaps:	31/329 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   329 NNLPDRQR-----VERGHPLTETQWLEFQTPDGRISDSAR-IKELIFRGGVVQSLRPEVWKFLLN 387
            |:|..||.     |:|..|:.:|:|..|....|.::.|.. |...|...|:...:|.|.||||..
Human     8 NSLSARQSASFILVKRKPPIDKTEWDSFFDESGHLAKSRDFICVNILERGLHPFVRTEAWKFLTG 72

  Fly   388 YYLWSDTHVERI-----ERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRS 447
            |:.|..:..||:     .|:..|::.....|.|  .:......||   .|.:..|.:|:::
Human    73 YFSWQSSQDERLTVDSMRRKNYKALCQMYEKIQ--PLLENLHRNF---TETRNNIARDIQK---- 128

  Fly   448 LQFFAGEDNPNLTL----LQGILMTYVMYNFDLGYVQGMSDLLAPILEIQV-NEVDTFWCFVGFM 507
              .:..:...|:.:    |:.||:...:.|....|.||..:::. :.::.| ::.:|||.|..|:
Human   129 --IYDKDPLGNVLIDKKRLEKILLLSYVCNTQAEYQQGFHEMMM-LFQLMVEHDHETFWLFQFFL 190

  Fly   508 ELVFTNFDIDQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNS-EDV 571
            :....:..|: .|:......:..||.|.:.....:::...:..:...|.|....::|...| :||
Human   191 QKTEHSCVIN-IGVAKNLDMLSTLITFLDPVFAEHLKGKGAGAVQSLFPWFCFCFQRAFKSFDDV 254

  Fly   572 LKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGI 636
            .:|||.|.|..||.||.:|.:.::|......::.......:||...|.|. ::|..:.:..|..:
Human   255 WRLWEVLLTGKPCRNFQVLVAYSMLQMVREQVLQESMGGDDILLACNNLI-DLDADELISAACVV 318

  Fly   637 YLQL 640
            |.:|
Human   319 YAEL 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	56/239 (23%)
TBC1D21	XP_006720472.1	TBC	62..287	CDD:214540	55/237 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820