Protein Alignment Tbc1d15-17 and TBC1D16

DIOPT Version :10

• Sequence 1: NP_608503.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: XP_024306345.1
• Gene: TBC1D16 / 125058
• HGNCID: 28356
• Length: 824
• Species: Homo sapiens
• Alignment Length: 872
• Identity: 204/872 - (23%)
• Similarity: 324/872 - (37%)
• Gaps: 290/872 - (33%)

  Fly    47 GVLLKKASAEHIADLNT-------SGSLSLVE----YSRSIA----------------------- 77
            |.||::||:: .:||.|       |||.|:::    ||::..
Human     4 GRLLRRASSK-ASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHPGYLCLYM 67

  Fly    78 ---EMPRRRLLLEWQPNDSIMIADDSQDQGDWALVDRISGRTRTTSECRAFNTRPIEPSGGATTR 139
               ||....|:|.|.||..|    ..||:.....:...|...|.....|...||    |.||:.:
Human    68 EKDEMLGATLILAWVPNSRI----QRQDEEALRYITPESSPVRKAPRPRGRRTR----SSGASHQ 124

  Fly   140 SRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEFFFQHGNADLFV--RSMRDQHL------- 195
            .          |..|:|..                   ....:.|:.|  :|:.|:.|
Human   125 P----------SPTELRPT-------------------LTPKDEDILVVAQSVPDRMLASPAPED 160

  Fly   196 ---------IENAE-TSRSGGEVYAILTT--------ENQKLKKTFAELDIG-QIKASQLPRESW 241
                     ::.|: .|:.......||:|        |.::.:....|.|.. ::.|..:.|:|.
Human   161 EEKLAQGLGVDGAQPASQPACSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSS 225

  Fly   242 LPNKLAGILGNIPDYVQPPFQRSP------KSRPGVLISGDRQTSPDNYQIIGL-----SG---- 291
            ..:.        .|....||..||      :||..|.:..|  :||.:....||     :|
Human   226 FDSD--------SDTFSSPFCLSPISAALAESRGSVFLESD--SSPPSSSDAGLRFPDSNGLLQT 280

  Fly   292 --------------------------------STNSACSSNGQ----SR-----------GGSAE 309
                                            .::.||:| ||    ||           ||..:
Human   281 PRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTS-GQLVVASRESQYKVFHFHHGGLDK 344

  Fly   310 KSPADSELE---TLNAQDEKIVNNLPDRQRVE-----------RGHP-------LTETQWLEFQT 353
            .|....:.:   .:..:|:::.   ||:..::           ..||       |..:.||....
Human   345 LSDVFQQWKYCTEMQLKDQQVA---PDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLN 406

  Fly   354 PDGRISDSARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLA 418
            ..|::.:..::::.||.||:..|:|.|||.|||.||....|..||...|.||..||..::.:.|:
Human   407 ELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLS 471

  Fly   419 MTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMS 483
            ||..:...|  :|..:..::|||.||||:.|||.||||||:..::.||:.|.:||..:||.||||
Human   472 MTPEEHRAF--WRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMS 534

  Fly   484 DLLAPILEIQVNEVDTFWCFVGFME-LVFTNFDIDQAGMKTQFAQ-------------------- 527
            ||:||||...::|.||||||||.|: .:|.:...|: .|:.|..:
Human   535 DLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDE-DMEKQLEEWTWETAPKCALRVGSLPGHG 598

  Fly   528 -------------------------------------IRRLIEFANAPLFNYMRS--HDSDNMYF 553
                                                 :|.|:...:...:.::.|  .|...|.|
Human   599 AAASVLPRPGTTLCLTLDHTTASGTVRSGRNWQRQLYLRELLRLTHVRFYQHLVSLGEDGLQMLF 663

  Fly   554 CFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVN 618
            |.||||:.:|||....:.|::||..|.......|||...|||:......:|:.|....::|.|..
Human   664 CHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFG 728

  Fly   619 ELSGNIDVQKTLQVAEGIYLQLKGSETLP---NDIRSIIGEPL-----LPAA------AGEEI-- 667
            .|:.:::.:..|:.|..:..|.:....:|   :|:..:.|..:     :||.      .|.|.
Human   729 NLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCP 793

  Fly   668 DGGMVD-----------EEPTYSDDGF 683
            .||.|:           :.|....|||
Human   794 YGGTVEMPSPKSLREGKKGPKTPQDGF 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_608503.1	TBC	369..598	CDD:214540	97/288 (34%)
TBC1D16	XP_024306345.1	TBC	424..709	CDD:214540	96/287 (33%)