DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and TBC1D8

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_005263919.1	Gene:	TBC1D8 / 11138	HGNCID:	17791	Length:	1162	Species:	Homo sapiens

Alignment Length:	483	Identity:	101/483 - (20%)
Similarity:	175/483 - (36%)	Gaps:	157/483 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   279 TSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIVNNLPDRQRVERGHP- 342
            ||.|: .:..|...:.|.||.:   |.|         :||.:::|:    :...::::....||
Human   426 TSADD-DMASLVFHSTSMCSDH---RFG---------DLEMMSSQN----SEESEKEKSPLMHPD 473

  Fly   343 --LTETQWLEFQTPDGRIS-----------------------DSARIKELIFRGGVVQSLRPEVW 382
              :|..|....|:||.|:|                       .:.:|::|:.. |:.:|||..:|
Human   474 ALVTAFQQSGSQSPDSRMSREQIKISLWNDHFVEYGRTVCMFRTEKIRKLVAM-GIPESLRGRLW 537

  Fly   383 KFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRER-------KC----- 435
                  .|:||                          ..|..|:..||...       ||
Human   538 ------LLFSD--------------------------AVTDLASHPGYYGNLVEESLGKCCLVTE 570

  Fly   436 QIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTF 500
            :||:|:.|:......|..|  ..:..|:.:|..|...|..:||.|.| ::|..:|.:...|.:.|
Human   571 EIERDLHRSLPEHPAFQNE--TGIAALRRVLTAYAHRNPKIGYCQSM-NILTSVLLLYTKEEEAF 632

  Fly   501 WCFVGFMELVFTNF--------DIDQA-------GMKTQFAQ-IRRLIEFANAPL-------FNY 542
            |..|...|.:..::        .:||:       |...:.|: :..|...|:..|       .:.
Human   633 WLLVAVCERMLPDYFNHRVIGAQVDQSVFEELIKGHLPELAEHMNDLSALASVSLSWFLTLFLSI 697

  Fly   543 MRSHDSDNMYFCFRW----------LLVWYKRELNSEDVLKLWE-----CLWTRL---------- 582
            |....:.|:..||.:          |.|   .|.|:||:....:     .:.:|.
Human   698 MPLESAVNVVDCFFYDGIKAIFQLGLAV---LEANAEDLCSSKDDGQALMILSRFLDHIKNEDSP 759

  Fly   583 --PCPNFHLLFSVAILDQETRVIIDSQYEFTEILKHVNELSGNIDVQKT--LQVAEGIYLQLKGS 643
              |..:.|..||.   |||...:.|    .:::::...|..|:..|::.  |:....|.: |:|.
Human   760 GPPVGSHHAFFSD---DQEPYPVTD----ISDLIRDSYEKFGDQSVEQIEHLRYKHRIRV-LQGH 816

  Fly   644 E--TLPNDIRSIIGE-PLLPAAAGEEID 668
            |  |..|.:|.:|.| .:||....|..|
Human   817 EDTTKQNVLRVVIPEVSILPEDLEELYD 844

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	57/290 (20%)
TBC1D8	XP_005263919.1	PH-GRAM1_TBC1D8	178..276	CDD:270156
		PH-GRAM2_TBC1D8	318..413	CDD:270160
		TBC	527..733	CDD:214540	51/243 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900