DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and tbc1d10c

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_005173203.1	Gene:	tbc1d10c / 101887140	ZFINID:	ZDB-GENE-130125-1	Length:	1383	Species:	Danio rerio

Alignment Length:	454	Identity:	88/454 - (19%)
Similarity:	153/454 - (33%)	Gaps:	136/454 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   345 ETQWLEFQTPDGRISD--SARIKELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSI 407
            |::||...|...::.:  |.::|... :.|:..|:|.:.|..|..           .:.||:|:.
Zfish    50 ESKWLGLMTQWEQVMEKKSHKVKSQC-QKGIPASVRIKCWPLLCG-----------AKDRKEKNS 102

  Fly   408 EYYNMKAQ------WLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQF---FAGEDNPNLTLLQ 463
            ..||...:      |:.:                 |::|   |||...|   |..:|......|.
Zfish   103 TLYNSLVEAPDHQGWIEI-----------------IKRD---TDRQFPFHEMFLSKDGHGQKDLL 147

  Fly   464 GILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFD--------IDQAG 520
            .:|..|..|..|.||.|.... :|.:|.:.:...:.|||.|...||....:.        .|.|.
Zfish   148 EVLKAYTQYRPDEGYCQAQGP-VAAVLLMNMPAEEAFWCLVQISELYLPGYYSPLLEGVLFDAAV 211

  Fly   521 MKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCP 585
            :.   :.:::|...|:    .:::....:.:.|...||:..:.|.|....:|::|:..:    |.
Zfish   212 LS---SVLKKLCPAAH----KHLQGQGVEPLMFATDWLMCLFSRHLPFNTLLRVWDLFF----CY 265

  Fly   586 NFHLLFSVAIL-------DQETRVIIDSQYEFTEILKHVNELSGNIDVQKTLQVAEGIYLQL--- 640
            ...:||.||::       |...|...|.|.|..|.|:.|.:...|......:.....:.|.|
Zfish   266 GVRVLFQVAVVLVRRCLGDGRLRKECDGQMETLERLRSVKQRVQNEQTDAFINEVCSVSLSLADL 330

  Fly   641 -------------------------------------------------KGSETLP-NDIRSIIG 655
                                                             |||.|:| ....|.:.
Zfish   331 QKQTEKELEKWKKDRPNSTFDPRGRCHGHRMAWERAQNKQKEQEKKERQKGSLTIPIMRSHSSLS 395

  Fly   656 EPLL--------PAAAGEEIDGGMVDEEPTYSDDGFDELVKE-----LTPEEKVRQQALLEEAC 706
            ..||        .....||.|||......:..::..:|.::.     :..|:|.:|..||::.|
Zfish   396 PSLLRKKWRKRSSKTDTEEWDGGGRKSTRSLMEESDEEEIRRRSLCAVIGEQKAKQDRLLDDLC 459

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	51/252 (20%)
tbc1d10c	XP_005173203.1	TBC	77..278	CDD:214540	51/243 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810