DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and TBC1D3K

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_006722298.1	Gene:	TBC1D3K / 101060351	HGNCID:	51245	Length:	610	Species:	Homo sapiens

Alignment Length:	266	Identity:	61/266 - (22%)
Similarity:	108/266 - (40%)	Gaps:	52/266 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 GILGNIPDYVQ-------PPFQRSPKSRPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRG 305
            ||:.:.|.:..       |||   |...||:....:|..:...:......|...:.|||:
Human    50 GIVQSCPSWESAPQEGPCPPF---PVPSPGLSPELERDRASPFWGSAPRLGPLQAPCSSS----- 106

  Fly   306 GSAEKSP-ADSELETLNAQDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIF 369
             :....| :::||..|.|::.|.:     |:.:.|     :::|::......:...|.::.:..:
Human   107 -ALPGLPYSETELPPLTAREAKQI-----RREISR-----KSKWVDMLGDWEKYKSSRKLIDRAY 160

  Fly   370 RGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSI-EYYNMKAQWLAMTTTQEANFCGYRER 433
            : |:..::|..:|..|||           ||..|.|:. .|..||.:....:           |.
Human   161 K-GMPMNIRGPMWSVLLN-----------IEEMKLKNPGRYQIMKEKGKKSS-----------EH 202

  Fly   434 KCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVD 498
            ..:|::||..|.|...||..........|..||:.|..||.::||.:.:|.:.|..| :.:.|.|
Human   203 IQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPEVGYCRDLSHIAALFL-LYLPEED 266

  Fly   499 TFWCFV 504
            .||..|
Human   267 AFWALV 272

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	37/137 (27%)
TBC1D3K	XP_006722298.1	TBC	160..373	CDD:214540	37/137 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900