Protein Alignment Tbc1d15-17 and Tbc1d14

DIOPT Version :9

• Sequence 1: NP_001259806.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: NP_001106833.1
• Gene: Tbc1d14 / 100855
• MGIID: 1098708
• Length: 714
• Species: Mus musculus
• Alignment Length: 679
• Identity: 140/679 - (20%)
• Similarity: 240/679 - (35%)
• Gaps: 211/679 - (31%)

  Fly    47 GVLLKKASAEHIADLNTSGSL---------------SLVEYSR-SIAEMPRRRLLLEWQPNDSIM 95
            |::.|.:|...:.|.|.|.|:               ||.:... ||...||...:.::.|:..:.
Mouse    10 GLMAKVSSGTKMTDGNLSTSMNGVALMGILDGRQGDSLQDLQHLSIKAAPRSLSVPDYGPSLKLG 74

  Fly    96 IADD-----SQDQGDWAL--------------VDRISGRTRTTSECRAFNT-------RPIEPSG 134
            ..:|     |.|.|...|              |.|....:....| |||.:       .|..|:
Mouse    75 ALEDRHSLQSVDSGIPTLEIGNPEPVPCSVVHVKRKQSESEIVPE-RAFQSACPLPSCTPSAPT- 137

  Fly   135 GATTRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVH-----SEFFFQHGNADL--------- 185
             .:.|.:|:|               ::..|.|.|.:.|.     |:...:..|..:
Mouse   138 -CSEREQVVR---------------KSSTFPRTGYDSVKLYSPTSKALSRSDNVSVCSVSSLGTE 186

  Fly   186 --FVRSMRDQHLIENAETSRSGGEVYAILTTEN-------------------------------- 216
              ...|:.::.:::...||.|.    ||:|.||
Mouse   187 LSTTLSVSNEDILDLMVTSNSS----AIVTLENDDDPQFTDVTLSSINETSDLHQQDCVAETEEG 247

  Fly   217 QKLK------KTFAELDIGQIKASQLPRESWLPNKLAGILGNIP--DYVQPPFQRSPK------S 267
            :|||      ..|....:.:.:.::|.|:..|..||   .|.:|  :..|...:::.|      .
Mouse   248 RKLKLLHPFSHFFTRNLLARKQNARLDRQRDLGWKL---FGKVPLRETAQKDSKKTQKEYEDKAG 309

  Fly   268 RPGVLISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNAQDEKIV---- 328
            ||      .|..||.......|.....|..:...:.|..:....||: |.:....|.|::|
Mouse   310 RP------SRPPSPKQNVRKNLDFEPLSTTALILEDRPANLPAKPAE-EAQKHRQQYEEMVLQAK 367

  Fly   329 -----------NNLPDRQRVER--GH----------PLTETQWLEFQTPDGRISDSARIKELIFR 370
                       ..|.:|.:||.  |:          |..||.|.           |.::::|.::
Mouse   368 KRELKEAQRRRKQLEERCKVEESIGNAVLTWNNEILPNWETMWC-----------SKKVRDLWWQ 421

  Fly   371 GGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNM-----KAQWLAMTT------TQE 424
             |:..|:|.:||...:...| :.||            |.:::     |.:|.:::|      .::
Mouse   422 -GIPPSVRGKVWSLAIGNEL-NITH------------ELFDICLARAKERWRSLSTGGSEVENED 472

  Fly   425 ANF-CGYRERKCQIEK-DVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLA 487
            |.| ...||...::.| |:.||..:|..|. :..|...:|..||..|..|..|:||||||| .:|
Mouse   473 AGFSAADREASLELIKLDISRTFPNLCIFQ-QGGPYHDMLHSILGAYTCYRPDVGYVQGMS-FIA 535

  Fly   488 PILEIQVNEVDTFWCFVGFM----ELVFTNFDIDQAGMKTQFAQIRRLIEFANAP-LFNYMRSHD 547
            .:|.:.::..|.|..|...:    ::.|  |.:|...|.|.||......| .|.| ||.:.:.::
Mouse   536 AVLILNLDTADAFIAFSNLLNKPCQMAF--FRVDHGLMLTYFAAFEVFFE-ENLPKLFAHFKKNN 597

  Fly   548 SDNMYFCFRWLLVWYKRELNSEDVLKLWE 576
            .....:...|:...|.:.|..:...::|:
Mouse   598 LTADIYLIDWIFTLYSKSLPLDLACRIWD 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	37/201 (18%)
		TBC	369..598	CDD:214540	57/226 (25%)
Tbc1d14	NP_001106833.1	ARGLU	<350..>392	CDD:373772	8/42 (19%)
		TBC	419..651	CDD:214540	57/227 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810