DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Tbc1d15-17 and tbc1d25

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_031746851.1	Gene:	tbc1d25 / 100495342	XenbaseID:	XB-GENE-876960	Length:	651	Species:	Xenopus tropicalis

Alignment Length:	392	Identity:	116/392 - (29%)
Similarity:	187/392 - (47%)	Gaps:	60/392 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   203 RSGGEVYAILTTENQKLKKTFA---------ELDIGQIKASQLPRESWLPNKLAGILGNIPDYVQ 258
            :.|.|.|..|.:| ..|...||         ::||...:.|.| .|.|             |.:
Frog    21 KQGHETYLALVSE-WDLANAFAAASQPFLQLKIDIKPSEDSPL-LEDW-------------DII- 69

  Fly   259 PPFQRSPKSRPGV-LISGDRQTSPDNYQIIGLSGSTNSACSSNGQSRGGSAEKSPADSELETLNA 322
                 |||...|. |..||::.      :......|.|..|..|::      .:.....|....:
Frog    70 -----SPKDVIGTDLFVGDKRA------LASALPFTQSILSQVGRT------LTRVQQALSWTYS 117

  Fly   323 QDEKIVNNLPDRQRVERGHPLTETQWLEFQTPDGRISDSARIKELIFRGGVVQSLRPEVWKFLLN 387
            .|.|     |.:.      ||:::::..:.:.:|:::....::..|:.|||..|||..||::|||
Frog   118 DDVK-----PFKP------PLSDSEFHTYLSHEGQLTRPEELRLRIYHGGVEPSLRKVVWRYLLN 171

  Fly   388 YYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANFCGYRERKCQIEKDVKRTDRSLQFFA 452
            .|....:..||::..|.|:.|||.:|.:||.....::..|.     :..:.|||.||||:..::|
Frog   172 VYPDGLSGQERMDYMKCKTREYYQLKGEWLQRCGAEDLEFI-----QGNVMKDVLRTDRTHPYYA 231

  Fly   453 G-EDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFMELVFTNFDI 516
            | ||||:|..|..:|.||.:.:..:.|.|||||:.:|||.:..||...|.||.|.|:.:..||.:
Frog   232 GSEDNPHLQALHDLLSTYAVTHPQVSYCQGMSDIASPILAVMDNEAHAFICFCGIMKRLEGNFRM 296

  Fly   517 DQAGMKTQFAQIRRLIEFANAPLFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTR 581
            |...|..:|..::.|:..::....:|:.|..:|::.||:||||:..|||...||.|::.|.:|:.
Frog   297 DGECMSVKFCHLKLLLRHSDPDFHSYLLSRGADDLLFCYRWLLLELKREFAFEDALRMLEVMWSS 361

  Fly   582 LP 583
            ||
Frog   362 LP 363

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	82/216 (38%)
tbc1d25	XP_031746851.1	TBC	153..366	CDD:214540	82/216 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1495285at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010