Protein Alignment Tbc1d15-17 and tbc1d12b

DIOPT Version :9

• Sequence 1: NP_001259806.1
• Gene: Tbc1d15-17 / 33184
• FlyBaseID: FBgn0031233
• Length: 715
• Species: Drosophila melanogaster
• Sequence 2: XP_005169505.1
• Gene: tbc1d12b / 100332088
• ZFINID: ZDB-GENE-121214-108
• Length: 771
• Species: Danio rerio
• Alignment Length: 697
• Identity: 140/697 - (20%)
• Similarity: 229/697 - (32%)
• Gaps: 196/697 - (28%)

  Fly     8 DRCHQVQLGVFNES--------QLSSVEE-------DVQNLPQQGTGNILFTHDGVLLKKASAEH 57
            ||...:..|:|:.|        ||.|.:|       |..|||           .|..|....|.|
Zfish    54 DRQENIMQGMFSNSGASQREKGQLQSSQEHEATESCDEVNLP-----------CGAKLPNGHASH 107

  Fly    58 IA-------DLNTSGSLSLVEYSRSIAEMPRRRLLLEWQPNDSIMIADDSQDQGDWALVDRISGR 115
            .|       ..:.:||....|....||             |..:::  ||...||.......||.
Zfish   108 NAPERVACKSSSPAGSCVSSEDDHGIA-------------NGELLV--DSGSAGDAVSSAFCSGE 157

  Fly   116 TRTTS----ECRAFNTRPIEPSGGATTRSRVMRAQLEDLSSVEVRHRGQTIRFMRKGANGVHSEF 176
            |...:    |.:|..|.........::....:..|..:.:..::..|..|.....|.:....|..
Zfish   158 TPDEAGESLETQAGETLEALDQAERSSTDHCLGLQSSECNEGKLHRRSSTSPSPLKHSLRTFSSS 222

  Fly   177 FFQHGNADLFVRSMRDQHLIENAETSRSGGEVYAILTTENQKLKKTFAELDIGQIKASQLPRESW 241
            .|.  |.|....|..|..  :..||          .:|.::.....|.::.:......::.|...
Zfish   223 TFL--NTDSASLSPNDDD--DEDET----------FSTSDRPDDLRFMDVSLKSRNTYEISRRQS 273

  Fly   242 LPNKLAGILG-------------NIPDYVQPPF----QRSPKSRPGVLISG-------------- 275
            .|:.:.|:|.             .|.|......    ||..:|.||..:.|
Zfish   274 APDNIPGVLSVAAVDLTLGQRKQGISDIFSRSLFTRKQREAQSAPGWKLFGKVPLRESPPKDSKT 338

  Fly   276 -DRQTSPDNYQIIGL-----SGSTNSACSSNGQSRGGSAEKSPADSELETLNA-----QDEKIVN 329
             .::::|.|...:..     ||...:....:|||....|:....:.|.|.|:.     :|...
Zfish   339 IQQESNPGNLTSVSTPNLLSSGEYEAKVCKSGQSPSLPAQSRRKNLEFEPLSTTALILEDRPA-- 401

  Fly   330 NLP-------DRQRVERGHPLTETQWLEFQTPDGR------------------------------ 357
            |||       .|.|.|....:.|.:..|.:....:
Zfish   402 NLPAKSEEEAQRHRQEYDEMVAEAKKRELKEAQKKKKQMKERFKQEESIANAMVVWNTEILPNWE 466

  Fly   358 -ISDSARIKELIFRGGVVQSLRPEVWKFLLNYYL--WSDTHVERIERRKQKSIEYYNMKAQWLAM 419
             :..:.|:::|.:: |:..::|.:||...:...|  .||.:...:.|.|::          |.:
Zfish   467 SMRGTRRVRDLWWQ-GLPPNVRGKVWSLAVGNELNITSDLYEIFLSRAKER----------WKS- 519

  Fly   420 TTTQEANFCGYRERKCQIEKDVKRTDR--SLQ-------------FFAGEDNPNLTLLQGILMTY 469
                      :||...:||.||...||  ||.             |...:..|...||..:|..|
Zfish   520 ----------FRETGSEIESDVDSADRESSLDLIKLDISRTFPSLFIFQKGGPYHDLLHSVLGAY 574

  Fly   470 VMYNFDLGYVQGMSDLLAPILEIQVNEVDTFWCFVGFM----ELVFTNFDIDQAGMKTQFAQIRR 530
            ..|..|:||||||| .:|.:|.:.:.|.|.|..|...:    ::.|  |.:|...|...||....
Zfish   575 TCYRPDVGYVQGMS-FIAAVLILNLEEADAFIAFANLLNKPCQMAF--FRVDHELMLKYFAAFEV 636

  Fly   531 LIEFANAP-LFNYMRSHDSDNMYFCFRWLLVWYKRELNSEDVLKLWE 576
            ..| .|.| |||:.:|::.....:...|:...|.:.|..:...::|:
Zfish   637 FFE-ENLPRLFNHFKSYNLTPDLYLIDWIFTLYAKSLPLDVACRVWD 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	30/164 (18%)
		TBC	369..598	CDD:214540	58/230 (25%)
tbc1d12b	XP_005169505.1	TPX2	407..>451	CDD:284337	5/43 (12%)
		TBC	478..708	CDD:214540	58/231 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810