DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Tbc1d15-17 and tbc1d2b

DIOPT Version :9

Sequence 1:	NP_001259806.1	Gene:	Tbc1d15-17 / 33184	FlyBaseID:	FBgn0031233	Length:	715	Species:	Drosophila melanogaster
Sequence 2:	XP_002666912.2	Gene:	tbc1d2b / 100330777	ZFINID:	ZDB-GENE-100922-148	Length:	946	Species:	Danio rerio

Alignment Length:	873	Identity:	166/873 - (19%)
Similarity:	296/873 - (33%)	Gaps:	305/873 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 LFTHDGVLLKKASA---------------EHIADLNTSGSLSLVEYSRSIAEMPRRRL--LLEW- 88
            |:.|.|::.:.|.|               :...:|:..|.:........:|: |...|  |.:|
Zfish   150 LYPHTGLVARDAEAMPYEKPSESMESVRNDFALELDNDGLIGHQTAHVPVAQ-PTAALSSLRQWG 213

  Fly    89 ----------------QPNDSIMIADDSQDQGDWALVDRISGRTRTTSECR-------------- 123
                            :...|:.....|:   ||.:||..: :....|:|:
Zfish   214 SEIRNSMSHLRPGRAGENRRSVFYTGGSE---DWEMVDPPT-KDPAPSDCQHRESSSHFNRSSIG 274

  Fly   124 -AFN---------TRPIEPSGGATTRS-----------RVMRAQLEDLSSVEVRHRGQTIRFMRK 167
             ||.         .||.....|....|           ::.:.||      .::.:.:.|..:::
Zfish   275 SAFTFDFRNPSKIKRPFHSGSGKPNHSAESSPVEYNETKISKLQL------RIQSQQEEISQLQE 333

  Fly   168 GANGVHSEFFFQHGNADLFVRSMRD------------QHLIENAETSRSGGEVYAILTTENQKLK 220
            ..|.:..|...|.....|..:::|.            .|.:|..|..::       ||..:.::|
Zfish   334 QENKLREELGSQKELVRLLQKTLRSAQCDWPSTVGPHNHYLEENEVDKA-------LTERDTQIK 391

  Fly   221 KTFAELDIGQIKASQLPRESWLPNKLAGI----------LGNIPDYVQPPFQRSPK-SRPGVLIS 274
            ...:.::     ...|.:|| |..:|.|:          ||.:.:.:|...:...| |:|    |
Zfish   392 DLCSHME-----KLALEKES-LQQELKGLKIKVGEINEQLGMLMETIQAKDEVIMKLSQP----S 446

  Fly   275 GDRQT------SPD-------------------------NYQIIGLSGSTNSACSSNGQSRGGSA 308
            |:.:|      ||.                         |.:||.|     :....|.:||....
Zfish   447 GEGETQSAECNSPSVTREQQELNTLKDSLQGYKSQNKFLNKEIIEL-----TVLRRNAESREKLL 506

  Fly   309 E------------------------KSPADSELETLNAQDEKIVNNLPDRQRVE----RGHP--- 342
            |                        |||..|..|..::.| .|...|.|..:||    :.||
Zfish   507 EAKYNSLEAKLCQVESKYLVLLQEVKSPVCSSSEQTHSGD-VITRLLEDALQVESTDQQEHPVLK 570

  Fly   343 ---LTETQWLEFQT-PDGR-------------------ISD---SARIK---------------- 365
               ::|.....|:| |:..                   ::|   |.|:|
Zfish   571 PNAVSEYDIYGFKTVPEEEDEEEKLEAKKRALDLKSLSLTDQETSVRVKWDNYLAITMNREMVRS 635

  Fly   366 ---ELIFRGGVVQSLRPEVWKFLLNYYLWSDTHVERIERRKQKSIEYYNMKAQWLAMTTTQEANF 427
               :.:.||||....|.:||.:.:::      ||::: |..|....|:|:    |.|...:....
Zfish   636 PDLKALMRGGVPHIHRSKVWSWCVSF------HVKKM-RDCQPKDYYHNL----LCMANDKPNPA 689

  Fly   428 CGYRERKCQIEKDVKRTDRSLQFFAGEDNPNLTLLQGILMTYVMYNFDLGYVQGMSDLLAPILEI 492
            |.      |||.|:.||..:.:.::..|:..:..|:.:|:.:...|.|:||.||: :.||.|..:
Zfish   690 CK------QIELDLLRTLPNNKHYSSPDSDGIQKLRNVLLAFSWRNPDIGYCQGL-NRLAAIALL 747

  Fly   493 QVNEVDTFWCFVGFMELVFTNFD----------IDQAGMK-TQFAQIRRLIEFANAPLFNYMRSH 546
            .:::.|.|||.|..:| ||...|          :||...| ..:.::.|        |..:...:
Zfish   748 YLDQEDAFWCLVAIVE-VFMPHDYYTKTLLGSQVDQRVFKDLMYEKLPR--------LHAHFEHY 803

  Fly   547 DSDNMYFCFRWLLVWYKRELNSEDVLKLWECLWTRLPCPNFHLLFSVAILDQETRVIIDSQYEFT 611
            ..|.....|.|.||.:...:.|:.:.|:|:......|...|.  |::|:...:....:..|...|
Zfish   804 KVDFSLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKIIFR--FALALFKYKEEEFLKLQDPMT 866

  Fly   612 EILKHVNELSGNI-DVQKTLQVAEGIYLQLKGSETLPNDIRSIIGEPLLPAAAGEEIDGGMVDEE 675
             |.|::...:..| |.:|.:.:|   ::.:.     |..:|.|                   ...
Zfish   867 -IFKYLRYFTRTILDARKLMAMA---FVDMN-----PFPLRQI-------------------QNR 903

  Fly   676 PTYSDDGFDELVKELTPEEKVRQQALLE 703
            .|:.   .:::..|||..|.:||..|.|
Zfish   904 RTFH---LEKVRLELTELEAIRQTFLRE 928

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Tbc1d15-17	NP_001259806.1	DUF3548	37..>191	CDD:192931	33/217 (15%)
Tbc1d15-17	NP_001259806.1	TBC	369..598	CDD:214540	60/239 (25%)
tbc1d2b	XP_002666912.2	PH_TBC1D2A	37..137	CDD:269966
		PH	37..129	CDD:278594
		CtIP_N	307..415	CDD:287457	20/126 (16%)
		TPR_MLP1_2	313..434	CDD:285204	22/139 (16%)
		USP8_interact	317..>359	CDD:286082	8/47 (17%)
		TBC	643..859	CDD:214540	60/244 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5210
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810