DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11617 and IRX1

DIOPT Version :9

Sequence 1:	NP_001245817.1	Gene:	CG11617 / 33183	FlyBaseID:	FBgn0031232	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_077313.3	Gene:	IRX1 / 79192	HGNCID:	14358	Length:	480	Species:	Homo sapiens

Alignment Length:	167	Identity:	51/167 - (30%)
Similarity:	74/167 - (44%)	Gaps:	33/167 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 HSRRAWPPEEELHPASRATKRLFTPDIKRMLKDWLIRRRENPYPSREEKKQLAAETGLTYTQICN 77
            |:..|:.|..:.........:..|.:....||.||...|:||||::.||..||..|.:|.||:..
Human   112 HTAPAYYPYGQFQYGDPGRPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVST 176

  Fly    78 WFANWRRKLKNSEREKAKKSWGHLIKNYNHNARGNVEQFSISSEDSIWEEEMHSCPAEDDEGDDN 142
            ||||.||:||    ::.|.:||...|:.        |..::...|:..:.|    .|||||..|.
Human   177 WFANARRRLK----KENKVTWGARSKDQ--------EDGALFGSDTEGDPE----KAEDDEEIDL 225

  Fly   143 E-----EFSSHSTGSDGNANNE--------PSSPYKP 166
            |     :...|    ||:.:||        |.:|..|
Human   226 ESIDIDKIDEH----DGDQSNEDDEDKAEAPHAPAAP 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11617	NP_001245817.1	Homeobox_KN	46..84	CDD:283551	19/37 (51%)
IRX1	NP_077313.3	Homeobox_KN	145..184	CDD:399131	20/38 (53%)
		HARE-HTH	<188..247	CDD:412843	19/74 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..268		22/85 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	280..354
		IRO	<313..326	CDD:214716
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810