DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11617 and TGIF2

DIOPT Version :9

Sequence 1:	NP_001245817.1	Gene:	CG11617 / 33183	FlyBaseID:	FBgn0031232	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001186442.1	Gene:	TGIF2 / 60436	HGNCID:	15764	Length:	237	Species:	Homo sapiens

Alignment Length:	202	Identity:	50/202 - (24%)
Similarity:	78/202 - (38%)	Gaps:	65/202 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 KRNRRHSRRAWPPEEELHPASRATKRLFTPDIKRMLKDWLIRRRENPYPSREEKKQLAAETGLTY 72
            ||.||.:.    |:|.:                ::|:|||...|.|.|||.:||..|:.:|.|:.
Human    18 KRKRRGNL----PKESV----------------KILRDWLYLHRYNAYPSEQEKLSLSGQTNLSV 62

  Fly    73 TQICNWFANWRRKLKNSEREKAKKSWGHLIKNYNHNARG--------------NVEQFSISSEDS 123
            .||||||.|.||:|......|..|.    ...:..:.||              :|...|:.:..:
Human    63 LQICNWFINARRRLLPDMLRKDGKD----PNQFTISRRGGKASDVALPRGSSPSVLAVSVPAPTN 123

  Fly   124 IWEEEMHSCPAEDDEGDDNEEFSSHSTGSDGNANNEPSSPY--------KPILFVGSAGLTERIS 180
            :....:.|.|....:|:                  :|::|:        ||::..||. ||....
Human   124 VLSLSVCSMPLHSGQGE------------------KPAAPFPRGELESPKPLVTPGST-LTLLTR 169

  Fly   181 AQTGGKT 187
            |:.|..|
Human   170 AEAGSPT 176

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11617	NP_001245817.1	Homeobox_KN	46..84	CDD:283551	19/37 (51%)
TGIF2	NP_001186442.1	Homeobox_KN	36..75	CDD:399131	20/38 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..106		2/22 (9%)
		Repressive function	103..237		16/93 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..193		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..237
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810