DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11617 and Irx4

DIOPT Version :9

Sequence 1:	NP_001245817.1	Gene:	CG11617 / 33183	FlyBaseID:	FBgn0031232	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_061373.1	Gene:	Irx4 / 50916	MGIID:	1355275	Length:	515	Species:	Mus musculus

Alignment Length:	281	Identity:	72/281 - (25%)
Similarity:	102/281 - (36%)	Gaps:	73/281 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 TPDIKRMLKDWLIRRRENPYPSREEKKQLAAETGLTYTQICNWFANWRRKLKNSE------REKA 94
            |.:....||.||...|:||||::.||..||..|.:|.||:..||||.||:||...      |.|.
Mouse   151 TRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLKKENKMTWPPRNKC 215

  Fly    95 ---KKSWGHLIKNYNHNARGNVEQFSISSEDSIWEEEMHSCPAEDDEGDDNEEFSSHSTGSDGNA 156
               |:.:|          .|..|:   :.|:...||.:.|..:|...|.|::|............
Mouse   216 ADEKRPYG----------EGEEEE---AGEEESREEPLKSAKSEGHAGKDDKELELSDLEDFDPL 267

  Fly   157 NNEPS-----SPYKPILFVGSAGLTERISAQTGGKTKYKHQMMEKYMRDSSTAKTTSQQ------ 210
            :.|.|     :|::.:    .:| .|||.|.:.|....|.            |.||.:.
Mouse   268 DAETSECELKTPFQSL----DSG-PERIPASSDGPGTGKE------------ASTTLRMPLGTAG 315

  Fly   211 GTQLNKWLESAAK------FTPDRNNYHIEWNMTRQKASSNSSCGQAIFTTDVSGA-----GRGG 264
            |..::..||.|..      ..||..            |.......:|..|...:||     .:..
Mouse   316 GAVMDGDLERARNCLRSTVVVPDSG------------AEGGPPACEAKLTFAQAGAPPNLETKPR 368

  Fly   265 RWMLHHKDELEAAEALANLAF 285
            .|.|.|.....||.||:...|
Mouse   369 IWSLAHTATAAAATALSQTEF 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11617	NP_001245817.1	Homeobox_KN	46..84	CDD:283551	19/37 (51%)
Irx4	NP_061373.1	Homeobox_KN	161..200	CDD:368670	20/38 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..258		14/65 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..307		10/45 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900