DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11617 and MKX

DIOPT Version :9

Sequence 1:	NP_001245817.1	Gene:	CG11617 / 33183	FlyBaseID:	FBgn0031232	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001229631.1	Gene:	MKX / 283078	HGNCID:	23729	Length:	352	Species:	Homo sapiens

Alignment Length:	273	Identity:	87/273 - (31%)
Similarity:	121/273 - (44%)	Gaps:	48/273 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 KRLFTPDIKRMLKDWLIRRRENPYPSREEKKQLAAETGLTYTQICNWFANWRRKLKNSEREKAKK 96
            ||....|:.|.||.||.:.|:||||::.||..||..:.:|..|:.|||||.||:|||:.|: ...
Human    74 KRQALQDMARPLKQWLYKHRDNPYPTKTEKILLALGSQMTLVQVSNWFANARRRLKNTVRQ-PDL 137

  Fly    97 SWGHLIKNYNHNARGNVEQFSISSEDSIWEEEMHSCPAEDDEGDDNEEFSSHSTGSDGNANNEPS 161
            ||...||.||...:||.|:.|:||:|        || :||.|.......      ::|..|....
Human   138 SWALRIKLYNKYVQGNAERLSVSSDD--------SC-SEDGENPPRTHM------NEGGYNTPVH 187

  Fly   162 SP-YKPILFVGSAGL--TERISAQTGGKTKYKHQMMEKYMRDS---STAKTTSQQGTQLNKWLES 220
            .| .|....|..||:  ..|.|.......|||..::.:|:.||   ..|..|:..|....:  ..
Human   188 HPVIKSENSVIKAGVRPESRASEDYVAPPKYKSSLLNRYLNDSLRHVMATNTTMMGKTRQR--NH 250

  Fly   221 AAKFTPDRNNYHIEWNMTRQKASSNSSCGQAIFTTDV---------SGAGRGGRWMLHHKD---- 272
            :..|:.:      |:.......||:.:.|..::.||.         |.|.|.|    ..||
Human   251 SGSFSSN------EFEEELVSPSSSETEGNFVYRTDTLENGSNKGESAANRKG----PSKDDTYW 305

  Fly   273 -ELEAAEALANLA 284
             |:.||.||.|||
Human   306 KEINAAMALTNLA 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11617	NP_001245817.1	Homeobox_KN	46..84	CDD:283551	18/37 (49%)
MKX	NP_001229631.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	19..54
		Homeobox_KN	88..127	CDD:399131	19/38 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	159..189		10/44 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..301		11/67 (16%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151833
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	95	1.000	Inparanoid score	I5060
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D283391at33208
OrthoFinder	1	1.000	-	-		FOG0007188
OrthoInspector	1	1.000	-	-		oto89776
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR11211
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5569
SonicParanoid	1	1.000	-	-		X4615
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.930