DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11617 and IRX2

DIOPT Version :9

Sequence 1:	NP_001245817.1	Gene:	CG11617 / 33183	FlyBaseID:	FBgn0031232	Length:	294	Species:	Drosophila melanogaster
Sequence 2:	NP_001127694.1	Gene:	IRX2 / 153572	HGNCID:	14359	Length:	471	Species:	Homo sapiens

Alignment Length:	210	Identity:	58/210 - (27%)
Similarity:	81/210 - (38%)	Gaps:	70/210 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    30 ATKRLFTPDIKRMLKDWLIRRRENPYPSREEKKQLAAETGLTYTQICNWFANWRRKLKNSEREKA 94
            |.::..|.|....||.||...|:||||::.||..||..|.:|.||:..||||.||:||    ::.
Human   116 AYRKNATRDATATLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRRLK----KEN 176

  Fly    95 KKSW-------------GHLIKNYNHNARGNVEQFSISSED---SIWEEEM--HSCPA------- 134
            |.:|             |...::.:.:.....|....|:||   |:..:.:  |||.|
Human   177 KMTWAPRNKSEDEDEDEGDATRSKDESPDKAQEGTETSAEDEGISLHVDSLTDHSCSAESDGEKL 241

  Fly   135 ----------------------EDDEGDDNEEFSSHSTGSDGNANNEPSSPYKPILFVGSAGLTE 177
                                  ||||.||.|       |..|.|      |.||:......||..
Human   242 PCRAGDPLCESGSECKDKYDDLEDDEDDDEE-------GERGLA------PPKPVTSSPLTGLEA 293

  Fly   178 RI------SAQTGGK 186
            .:      :|..||:
Human   294 PLLSPPPEAAPRGGR 308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11617	NP_001245817.1	Homeobox_KN	46..84	CDD:283551	19/37 (51%)
IRX2	NP_001127694.1	Homeobox_KN	132..171	CDD:283551	20/38 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	176..373		30/146 (21%)
		IRO	322..339	CDD:214716
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	424..471
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900